ID W5MPB2_LEPOC Unreviewed; 2880 AA.
AC W5MPB2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Fibrillin 2 {ECO:0000313|Ensembl:ENSLOCP00000010221.1};
GN Name=FBN2 {ECO:0000313|Ensembl:ENSLOCP00000010221.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010221.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AHAT01002740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000010221; -.
DR Ensembl; ENSLOCT00000010234.1; ENSLOCP00000010221.1; ENSLOCG00000008383.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; W5MPB2; -.
DR OMA; HQCVACP; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000008383; Expressed in larva and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 26.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24040:SF13; FIBROPELLIN-1; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 4.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 33.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 46.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 43.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 29.
DR PROSITE; PS50026; EGF_3; 41.
DR PROSITE; PS01187; EGF_CA; 17.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2880
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868042"
FT DOMAIN 147..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 185..228
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 247..288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..388
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 453..493
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 494..533
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 534..575
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 576..616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 617..657
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 663..715
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 727..768
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 769..810
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..846
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 856..895
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 915..956
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 961..1012
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1033..1074
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1075..1117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1160..1201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1285..1322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1327..1367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1370..1410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1411..1452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1453..1489
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1494..1534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1539..1595
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1612..1653
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1654..1691
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1700..1753
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1771..1812
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1813..1854
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1855..1896
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1897..1932
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1936..1978
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1982..2021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2022..2059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2068..2123
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2139..2180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2181..2220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2262..2305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2306..2347
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2352..2405
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2417..2454
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2459..2499
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2500..2536
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2539..2581
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2582..2621
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2622..2658
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 151..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 498..508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 815..825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1901..1911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2586..2596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2880 AA; 313231 MW; 1E4A780019EDD1E1 CRC64;
FVLWGLGSVA LSALSVLTVT GQIPANHEKD QFKADEEKIS ALSRVRRRGQ QDFLRGPNVC
GSRFHSYCCP GWKTLPGGNQ CIVPICRNSC GDGFCSRPNM CTCSSGQIAP TCGSKSIQQC
NTRCMNGGSC AEDRCHCQKG YTGTYCGQPV CEDGCQNGGR CIGPNRCACV YGFTGPQCER
DYRTGPCFMQ VSNQMCQGQV SGIVCTKTLC CATIGRAWGH PCETCPAQPE PCRRGFIPNI
RTGACQDVDE CQAIPGLCQG GNCINTVGSY ECKCPKGHKQ NERTQKCEDI DECSTLQGVC
DGGQCINTVG GYSCICPPGY MQSADGTRCF DRRGGTCFSS LVNGRCAQEL TGLLSKMRCC
CELGRCWALG SVPEMCPVRG SDEYRRLCIQ GIPLGGFPEV DPGITGGRIN HFVPSELDPT
ITGERVQTGQ LHRPLPDFGE FKACIEKETL NQTVDICQRF TNLCLNGRCI PVPSSYRCEC
NMGFRQDVRG ECTDIDECSS NPCTNGDCVN TPGSYYCKCH SGFQRTPTKQ ACIDIDECLQ
NGVLCKNGRC VNTDGSFQCI CNAGFELTPD GKNCVDHDEC ATTNMCLNGM CINEDGSFKC
ICKPGFTLAA SGRYCIDVDE CQTPGMCMNG RCINTEGSFR CECLAGLAVG VDGRFCVDTH
MRSTCYGAIK KGVCVRPFPG AVTKSECCCA NSDHSFGEPC QPCPARNSAE FQALCGSGIG
FSVEGRDINE CALNPDICPN GVCENLRGSY RCICNSGYES DETGKNCVDI DECSVNRLLC
DNGLCRNMPG SYSCTCPKGY VFKPDSETCE DINECESSPC ANGICRNNAG SFVCECSAGS
KLDSTRLICV ADSLKGTCWL NIQDGRCEVN INGATLKSEC CATLGAAWGS PCERCEIDTA
CSRGFARSKG IVCEDVNECE VFPGVCPNGR CINTKGSFKC ECPEGLTLDG TGRLCVDVRL
EHCYLTWDED ECTLPIPRKF RMDVCCCSIG AAWGSECEAC PQPGSREYEA LCPRGPGFAN
RGDILTGRPF YKDIIECKVF PNICTNGKCQ NTIGSFRCRC DSGFALDTEG RNCTDIDECR
ISPDLCGSGT CVNTPGSFEC ECFEGYESGF MMMKNCMDID ECERNPMLCR GGSCENTEGS
YRCICPPGHQ LSPGGDACID INECDLSDSL CRNGKCVNVI GTYQCSCNSG YQATPDRQGC
VDIDECTIEN GGCDTHCTNS EGSYECACSD GYSLMPDHRS CTDVDECEDN PDICDGGQCT
NIPGEYRCLC YDGFMTSMDM KICVDVNECD LNPNICMFGD CENTKGSFIC HCQMGYSVKK
GTTGCTDVDE CEIGAHNCDL HASCVNVPGS FHCACQEGWV GNGIKCVDTD LDECANGTHQ
CSPSAKCLNI PGSYRCACAE GFSGDGYTCS DVDECAENVN LCENGQCLNT PGTYRCECEM
GFTPAPDSKS CQDIDECTFQ NICVFGTCKN LPGMFRCICD DGYELDRSGG NCTDIDECLN
PISCVNGLCK NTAGSYECNC PPDFELNPTG VGCVDTRVGN CYLEVGFRGD NGLSCSVEIG
VLVSRSSCCC SLGRAWGNPC EHCPAVNTTE YNTLCPGGEG FRTNPITILL EDIDECQELP
GLCQGGNCIN TFGSFQCECP SGYYLNDESR ICEDIDECIT HPGICGPGTC YNTLGNYTCV
CPQEYMQVNG GNNCMDMRKS LCYRNYNGTA CENELAFNIT KRLCCCAYNV GKAWNKPCET
CPTPGTSDYR TLCGNGFPGF YFDIETGKAV DIDECREIPG ICANGVCINQ IGSFRCECPT
GFSYNDLLLI CEDIDECSNG DNLCQRHADC INSPGSYRCE CSDGFRLSPN GACIDRNECL
EIPNVCSHGE CRDLLGGYQC VCHNGFKATP DRKMCMDVDE CERQPCGNGT CKNTVGSYNC
LCYPGFELTH NNDCIDIDEC RSSYGQLCRN GQCINSIGSF QCLCEEGYEL TPDGKNCIVK
TDINECLTLP GTCSPGTCQN LDGTFRCLCP PGYIVHNDNC IDINECDEDP NICLFGSCFN
NLGSFECVCR PGFVLSESGR RCYDTRESFC FTKFENSMCS APQPFNTTKA KCCCSKMPKE
GWGDPCELCP KEHEDAVAFQ ELCPFGYGTI PGKEDTREDV NECAENPGIC YNGHCINTDG
SFRCECPMGY TLNYTGVHCV DIDECSVGNP CGNGTCTNVI GGFECSCEEG FEPGPMMTCE
DINECGQNPL LCAFRCINTY GSYECTCPAG YVLRDDRRMC KDLDECSEGF HDCESRGMAC
KNLIGTFMCI CPVGMVRQPD GEGCQDENEC RTKPGICENG RCVNTLGSYI CDCNDGFQSS
ATRTQCIDYR EGFCFTEVLQ TMCQMSSSSR NPTTRSECCC DGGRGWGNQC DLCPLPGTGP
YKKLCPHGPG YTTNGTDIDE CRVMPNLCKN GQCINTMGSF RCHCKQGFTS DISGTSCVDM
DECVQSPKPC NFICKNTEGS YLCSCPRGYI LHEDGRTCKD LDECQTKQHN CQFLCVNTIG
GFTCKCPPGF TQHHTACIDN NECASQPSLC GARGICQNSP GSFSCECQRG FSLDSTGLSC
DDVDECVSNH RCQHGCQNML GSYRCSCPQG YIQHYQWNQC VDENECSNPN TCGAASCYNT
LGSFKCACPS GYSFDQFTTS CEDVNECSYF KNPCSYGCSN TEGGYLCGCP TGYYRVGQGH
CVSGMGFGKG QYLPLDGEGD EENALSPEAC YECKINGFGK KTGRKRRSSN QTALAEDQPI
SLASLDIESP LNLNLKISEL NPKEHILEVI PAIKPLTNHV RYVISSGNED GFFHIQQRGG
LSYLHTTKKK TWPGTYTLEI TSIPLYKQKD LNKLEDSKDR DYMTGELGEN LRMRLQIELQ
//
