ID W5MQ91_LEPOC Unreviewed; 446 AA.
AC W5MQ91;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Major facilitator superfamily domain containing 9 {ECO:0000313|Ensembl:ENSLOCP00000010550.1};
GN Name=MFSD9 {ECO:0000313|Ensembl:ENSLOCP00000010550.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010550.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000256|ARBA:ARBA00008335}.
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DR EMBL; AHAT01003416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006639309.1; XM_006639246.2.
DR AlphaFoldDB; W5MQ91; -.
DR STRING; 7918.ENSLOCP00000010550; -.
DR Ensembl; ENSLOCT00000010565.1; ENSLOCP00000010550.1; ENSLOCG00000008676.1.
DR GeneID; 102697710; -.
DR KEGG; loc:102697710; -.
DR CTD; 84804; -.
DR eggNOG; KOG2615; Eukaryota.
DR GeneTree; ENSGT00940000159390; -.
DR InParanoid; W5MQ91; -.
DR OMA; LQPAWRQ; -.
DR OrthoDB; 1831285at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000008676; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17390; MFS_MFSD9; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR PANTHER; PTHR23504; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10; 1.
DR PANTHER; PTHR23504:SF14; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 9; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..436
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 207..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 48343 MW; 93EBF48DEBA0756C CRC64;
MFNPRCSTFQ KPLRQRRFIL CMYFVGFMDL FGVSMIVPLL SHHVKSLGAT PTVAGIVGST
YGILQLFSST LVGSWSDVVG RRYSLVTCIL LSALGYGLLG LSTNIVLFIV ARIPVGIFKH
SLSICRALLS DLVSETERPL VMGHFNAASS VGFILGPVVG GYLTEHEGGF YTSSFICSGI
FLLNAGLVWM LPWNDTFKKT DLATAKTSKG SSNNIKRKHE DSDHVKESAA PRERFFQPAW
KQCSSVLLKI RALSSSDMWD VFLVRLLMAI AIMLYYSNFS LALEERFALK PKVTGYLISY
SSTLGALAGF LVGPVTKLYH NDMSSMLLHS SILTCSLIFL YATAPSVWQV VLCSTFFAIS
TTIGRTCITD LELRLGGAQA SGTLIGAGQS VTAVGRVLAP LLSGFAQEFS PCGPPSLGVV
LALAAVLLLI LKKPRGAKGE KRHPNL
//
