ID W5MSH2_LEPOC Unreviewed; 623 AA.
AC W5MSH2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Autophagy related 16 like 1 {ECO:0000313|Ensembl:ENSLOCP00000011331.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011331.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011331.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR EMBL; AHAT01012921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015217039.1; XM_015361553.1.
DR AlphaFoldDB; W5MSH2; -.
DR STRING; 7918.ENSLOCP00000011331; -.
DR Ensembl; ENSLOCT00000011347.1; ENSLOCP00000011331.1; ENSLOCG00000009283.1.
DR GeneID; 102693910; -.
DR CTD; 55054; -.
DR eggNOG; KOG0288; Eukaryota.
DR GeneTree; ENSGT00940000153936; -.
DR InParanoid; W5MSH2; -.
DR OMA; GRPCISP; -.
DR OrthoDB; 458014at2759; -.
DR Proteomes; UP000018468; Linkage group LG14.
DR Bgee; ENSLOCG00000009283; Expressed in bone element and 13 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0039689; P:negative stranded viral RNA replication; IBA:GO_Central.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF6; AUTOPHAGY-RELATED PROTEIN 16-1; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 15..205
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 334..375
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 378..419
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 420..461
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 556..587
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 589..623
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 246..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..55
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 95..229
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 255..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70103 MW; 394BA10393CA3478 CRC64;
MSGVRFRAEC SWKRHIAEQL KHRDRVQRQA FEEIIQQYNR LLEKADLQAV LAERRQTEKY
DIQNRHDLSP GADGGRSETL VQEMSQIRIK HQEELTELHK KRGELAQNVI ELNNQMQQKD
KEIQANEAKM LEYQQQIAQL EGECRELRSS LQDLERANQT LKDEYDALQI TFSALEEKLR
RTTEENQELI SRWMAEKAQE ANRLNAENEK DCRRRQAKLQ KELAEAAKEP LPIDQDDDIE
VLPEEAAEQA GDTSPTRGAC RTPSKRNSQQ PPGGLLDSIS NIFGLSESPI LGHHISDRSR
RRSLNSFGSS PENAEAHTGV CVEVRVPTTP LHVFDAHDGE VNAVRFSPGS RLMATGGMDR
KVKLWEVISG HCELKGTLTG SNAGITSIEF DSAGSYLLAA SNDFASRIWT VDDQRLRHTL
TGHSGKVLSA RFLLDNARIV SGSYDRTLKL WDLRSKVCIK TVFAGSSCND IVCTEQCVMS
GHFDKKVRYW DIRAESIVRE LELHGRVTSL DLNAERTELL ACSRDDLIKI IDLRTNAVRQ
TFSVQGFKCG SDWTRVTFSP DGSYIAAGSA DGTLYVWNVL TGKLDRTLGK HHSSTINAVA
WSPSGTYVVS VEKGSKAVLW SDL
//