ID W5MSP3_LEPOC Unreviewed; 712 AA.
AC W5MSP3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSLOCP00000011402.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011402.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01003459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015219526.1; XM_015364040.1.
DR AlphaFoldDB; W5MSP3; -.
DR STRING; 7918.ENSLOCP00000011402; -.
DR Ensembl; ENSLOCT00000011418.1; ENSLOCP00000011402.1; ENSLOCG00000009346.1.
DR GeneID; 102683961; -.
DR CTD; 11141; -.
DR eggNOG; KOG3971; Eukaryota.
DR GeneTree; ENSGT01090000260076; -.
DR HOGENOM; CLU_025552_0_1_1; -.
DR InParanoid; W5MSP3; -.
DR OMA; WRSSIVF; -.
DR OrthoDB; 3994459at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000009346; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR GO; GO:0045920; P:negative regulation of exocytosis; IBA:GO_Central.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890:SF22; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..712
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866491"
FT TRANSMEM 354..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 153..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 242..350
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 403..573
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 674..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 82151 MW; 4507E155957F5CE3 CRC64;
MKAPIPLLIL LYTSMTKSLK VVSKRGSVDG CTDWSVDYLK YKVLLGEPVR IKCALFYGYI
RANYTHAQSA GLSLMWYKST GHGDFEEPIP FDGVRMSKEE DAIWFRPAEL QDVGLYACVL
RNSTYCMKVS MSLTVAENDT DLCYNSKMRY FEKGELSKSK EITCPDIEDY VLPQREPNIV
WYKECKPKQW RQSIVRRRDT LIIREVREDD IGNYTCELQF GNFVVRRTTE LTVTAPLTDK
PPKVLFPSEN KMNILEVQIG SPANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDESRVRE
SDIRIIREHL GEQEVSISLT IDSVEESDLG NYSCYVENGN GRRQASILLH KRELMYTVEL
AGGLGAILLL LVCLVTLYKC YKIELMLFYR NHFGADEVDG ENKDYDAYLS YTKVDPEQWG
QETREEERFA LEILPDVLEK HYGYKLFIPE RDLIPTGSFT NDHYEDPRLL RAYIEDVARC
VDQSKRLIIV MTPSYVVRRG WSIFELETRL RNMLVTGEIK VILIECTELR GIMNYQEVEA
LKHTIKLLTV IKWHGPKCNK LNSKFWKHLQ YEMPFKRIEP ILAHEQVLDV SEQGPFGELQ
TVSAISMAAA TSTALATAHP DLRSTFHNTY HTQMRQKHYY RSYEYDVPPT GTLPPLTTLG
NQHTYCNIPM TLINGQRPQS KSPREQNLEE AHTNSAVLPL LPRETSISSV IW
//
