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Database: UniProt
Entry: W5MU05_LEPOC
LinkDB: W5MU05_LEPOC
Original site: W5MU05_LEPOC 
ID   W5MU05_LEPOC            Unreviewed;      2205 AA.
AC   W5MU05;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit a {ECO:0000313|Ensembl:ENSLOCP00000011864};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011864, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000011864, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000011864}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000011864}.
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DR   EMBL; AHAT01000045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01000046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01000047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01000048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000011885; ENSLOCP00000011864; ENSLOCG00000009682.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     95    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    186       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    304    325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    612    634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    689    711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1115   1134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1187   1206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1252   1274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1445   1464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1476   1498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1504   1523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1568   1590       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1661   1685       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1701   1736       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      707    734       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2205 AA;  251277 MW;  1930600070E55BC8 CRC64;
     MARFGDDVAG RLGSGDGGSE RSRNRQGVAV SSGGVSAAFK QSKAQRARTM ALYNPIPVRQ
     NCFTVNRSLF IFGEDNIVRK YAKKIIEWPP VCTPFEYMIL ATIIANCIVL ALEQHLPGDD
     KTPMSKRLEK TEPYFIGIFC FEAGIKIVAL GFVFHKGSYL RNGWNVMDFI VVLSGILATA
     EAQINTHVDL RTLRAVRVLR PLKLVSGIPS LQIVLKSIMK AMVPLLQIGL LLFFAILMFA
     IIGLEFYSGK LHHTCTQAPN ILDNETVDGS ELEFPCGFRE CPKKYNCTPD WIGPNDGITQ
     FDNILFAVLT VFQCITMEGW TTVLYNTNDA LGPTWNWLYF IPLIIIGSFF VLNLVLGVLS
     GEFAKERERV ENRRAFMKLR RQQQIERELN GYRAWIDRAE EVMLAEENKN SGTSALDVLR
     RATIKKSRME VIRREPSEDQ YADISSVGIP LARASIKSAK FGGASYCRRK ERMLRISIRR
     MVKSHTFYWT VLSLVALNTL CVAIVHHRQP EWLSTFLYYA EFLFLGLFLT EMFLKMYGLG
     PRLYFHSSFN CFDCGVIVGS IFEVVWGFFR PGMSFGISVL RALRLLRIFK ITKYWASLRN
     LVVSLMNSMK SIISLLFLLF LFIVVFALLG MQLFGGRFIF EDYTPTNFDT FPAAIMTVFQ
     ILTGEDWNEV MYNGIRSQGG VRSGMWSSIY FIVLTLFGNY TLLNVFLAIA VDNLANAQEL
     TKDEEEEEEA FNQKHALQKA KEVSPMSAPY LMAAERKRPF LYRKRAIHRS RHTFKIEAVG
     NLEALPDAQP LNAPNYFMSR RERRRRMTMS VWEQRTSQLR RRRQMSSREI LFSNPGEDLE
     RSASCPRHRK PIATDSLRRI PEPPIPEPEP LPGPEEKLGI TNHCQPPKEG RQSPRANGER
     SHRSTRRNRM ALGEGAATEE GARARRSSRH RHRERMEGKG KDSPHSEGSR SVSRERRLEE
     PERDLGEAKN GGNGKIECEG EQRLNETTPE PTETKPVTNS PKMEEQDVNE VLKSDNPPLQ
     PSKDTTMKPE TAENNPALLN QDKPSLNASI VIEVTGVQSP LELTPIAANS KDVEAAKTEK
     EEDGCSGPKP ANPDSMFIFK ASNPIRKACH YVVNLRYFEM CILLVIAASS IALAAEDPVS
     TNSEWNKVLR YFDYVFTGVF TFEMIIKMID QGLILHDGSY FRDLWNILDF IVVVGALIAF
     ALTNVMGNNK GRDIKTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVTSLK NVFNILIVYK
     LFMFIFAVIA VQLFKGKFFY CTDGSKDTEK ECQGFYIDYE KDKKEVKKRE WKRHDFHYDN
     IIWALLTLFT VSTGEGWPQV LQHSVDVTEE DRGPSRGNRM EMSIFYVVYF VVFPFFFVNI
     FVALIIITFQ EQGDKMMEEC SLEKNERACI DFAISAKPLT RYMPQNRQTF QYKVWHFVVS
     PSFEYTVLAM IALNTVVLMM KYYSAPTTYD QVLKHLNTAF TVLFSLECIL KIVAFGFLNY
     FRDTWNIFDF ITVLGSITEI VLTDFQLPNT FNMSFLKLFR AARLIKLLRQ GYTIRILLWT
     FVQSFKALPY VCLLIAMLFF IYAIIGMQVF GNIKLNDESH INQHNNFKTF FSALMLLFRS
     ATGESWQEIM LSCLSGKGCE TDPSSNSSTP IIKSDCGTDF AYFYFVSFIF FSSFLMLNLF
     VAVIMDNFEY LTRDSSILGP HHLDEFVRIW AEYDRAACGR IHYTDMYEML THMSPPLGLG
     KKCPAKVAYK RLVLMNMPVD EDMSVHFTST LMALIRTALE IKIARGGEDR QQLDAELQKE
     INVIWPHLSQ KSLDLLVPIH KASDMTIGKI YAAMMIMDYY KQSKAKKQRQ QLEEQKNAPM
     FQRMDASSLP QEILSSAKAL PFLQQSTGSG LTRGGFVALS PISPQEMFIH PRSPDMEMKE
     DFHAHHSLVM TDSSTMKRSF STIGDQRVNG LWLDEYSLER VSPDRLYRPR QRSYRGSGLK
     SDHRQPGDRE RGRSKERRHL LSPDVSRCNS EERSQHHSRE RKHSRSPSEG RSHTPHRQGT
     SSDSPVPSTS ESSTPRGRRQ LPQTPSRPRP HISYSPLVRR AHPSPPGDGS SPRTQEAECG
     DQAWGEGATS GQGGSHRSTP HRYISEPYLP LHEDYNSPDS AGLEETLTFE AAVATSFGRS
     NTISSAPPLR HSWQVPNGHF RNRLSQSSSV AGCELFSDTD EDDRC
//
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