ID W5MUC3_LEPOC Unreviewed; 492 AA.
AC W5MUC3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=THUMP domain containing 3 {ECO:0000313|Ensembl:ENSLOCP00000011982.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000011982.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000011982.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR EMBL; AHAT01020623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MUC3; -.
DR Ensembl; ENSLOCT00000012003.1; ENSLOCP00000011982.1; ENSLOCG00000009800.1.
DR GeneTree; ENSGT00530000063557; -.
DR HOGENOM; CLU_045692_0_0_1; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000009800; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 173..281
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 127..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54914 MW; E31E9355EB0BE4AA CRC64;
MSAEGLERAG EGPDPEDPIT VTIGATVPTG FEHSAAEEVG EKIGTDVRIS KDRGRIYFKT
THVNLPQIHR LRSVDNLFVV VEEFSDYCFK DTKEETLEDF QKLAAKLPWK WPLEVWKINN
SLKKKRSRQK IIQENGSEDS CSETLVKRED SHTEAEGSHT KSKQSSEISS DLDEKKDDVQ
DVKDGKKMIS AETASASGNG DVVEGGKDCE GPEAEGSSKL LKFRVTCNRA GDKHNFTSND
AARDFGGAVQ DLFQWKPDMT RFDIEVLLNI HNNEVVVGIA LTEESLHRRN ITHFGPTTLR
STLAYGMLRL CNPQISDVIV DPMCGSGAIP LEGALEWPHS FYMAGDNNGM AVNRTGNNIN
HIHKKRQSKE GTAWGLPIDT VQWDLCNLPM KTGSVDIIIT DMPFGKRMGS KKKNWDLYPS
CLKEMGRVCR PGSGKAVLLT QDKKCFAKAV SKMGYLWRKS HTVWVNVGGL HAAVYLLKRT
GLRTLEQRKS FW
//
