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Database: UniProt
Entry: W5MUS2_LEPOC
LinkDB: W5MUS2_LEPOC
Original site: W5MUS2_LEPOC 
ID   W5MUS2_LEPOC            Unreviewed;      1947 AA.
AC   W5MUS2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 28.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012131, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000012131, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000012131}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000012131}.
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DR   EMBL; AHAT01010434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01010435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000012152; ENSLOCP00000012131; ENSLOCG00000009914.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    392    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    710    728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    740    763       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    820    848       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    908    933       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1139   1158       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1179   1195       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1207   1226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1271   1291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1379   1402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1461   1479       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1491   1513       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1525   1544       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1682   1705       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    425       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      485    659       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      710    937       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      947   1134       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1138   1411       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1460   1715       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1719   1782       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED       14     41       {ECO:0000256|SAM:Coils}.
FT   COILED      427    457       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1947 AA;  221738 MW;  5014B976D9CB4484 CRC64;
     MATLLLPPGP DSLRRFTRES LAAIENRIAE EQARNAKQEY REDLGDVEPP KPRADLEAGK
     QLPRIFGDIP SELVGVPLDD FDSYYYNNQK TFIVLNKGKA IFRFSATPAL YIFSPFHPVR
     RASIKILVHS LFSLFIMCTI LTNCVFMAMS EPAQWAKYVE YTFTGIYTFE SLIKILARGF
     CIGPFTFLRD PWNWLDFSVI VMAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLA DVMILTVFCL SVFALIGLQL FMGNLRQKCV QNITDCYHNT STNGTNYYCK
     NKTWPSYQDF ISDEENYYKL EGAKDPLLCG NGSDAGRCPD GAVCLKIGKN PDYGYTSFDT
     FGWAFLALFR LMTQDYWENL YHQTLRSVGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE
     EQNQATIAEA WQKEKEFQEA MEQLRKEQQA IVNKVQETDS VLSPEMSPFP MKDTKERRNR
     KKKHKTLSEG AEDDAEDKTA KQDTEDRQRG NVFLARTLSS ANRRESQCSI FNFRSRNKES
     ETDFADDECS ANGDNASRTG SLVIPWSRRR TSAHSTSSHC SQGNTPTLNI NGKLNITVDR
     NGVSSLGPPS ALTLPVVMVD KVNTEDHALQ CQNEKTKTCV GVQNGKEPFQ RERALSAASV
     LTNAMEELEE SHQKCHPCWY RFAQHYLIWD CCPLWLKIKE WVKFGVMDPF LDLAITICIV
     LNTLFMALEH HPMTDDFNSM LSVGNLVFTG IFTAEMVFKI IALDPYYYFQ QGWNIFDSII
     VSLSLMELGL SNVEGLSVLR SFRLLRVFKL AKSWPTLNTL IKIIGNSVGA LGNLTLVLAI
     IVFIFAVVGM QLFGKSYQDC VCKISKDCTL PRWHMKDFFH SFLIVFRVLC GEWIETMWDC
     MEVAGQPLCI LVFMLVMVIG NLVVLNLFLA LLLSSFSADN LSAPDDDGEM NNLQIAIARI
     QRGINWLKIA ICDFFNGNFK KRRQKAKEAK AMTKLQRLGN HIEGNGTMGI IGRNGEKYVI
     SDGDSYMTNP NLTINVPIAP GESDVEFPEE DERSECSEDE EVKQKDEISL SEGSTVDLRK
     PGEEEDEFSE MAEEAMDPED CFPEMCVRRF PCCDINTTQG VGSIWWRLRK TCYRIVEHSW
     FETFIIFMIL LSSGALAFED INIEKRKVIK VILEYADKVF TYVFVLEMLL KWVAYGFKKY
     FTNYWCWLDF LIVDVSLISL IANTLGYSDF AAIKSLRTLR ALRPLRALSR FEGMRVVVNA
     LIGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFGKCVSK AGYQYNASHI NNRSECLAMN
     NMTLYYWTKV KVNFDNVGAG YLALLQVATF KGWMEIMYAA VDSRGLEEQP IKESNLYMYL
     YFVIFIIFGS FFTLNLFIGV IIDNFNQQKR KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK
     PIPRPLNPFQ GFFFDVVSKQ AFDIIIMILI CLNMVTMMVE TDDQSKRMED ILNKINLAFI
     VIFTGECCIK IMALRCYFFT VGWNIFDFVV VILSIVGIVL ADIIEKYFVS PTLFRVIRLA
     RIGRVLRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMAN FAYVKKQGGI
     DDMFNFETFG NSMICLFQIT TSAGWDSLLS PILNNSPEEC DANKTHTGTN AKGDCGNPSV
     GITFFVSYII ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFEMFYEV WEKFDPEATQ
     FIEYAKLSDF ADSLEEPLRI AKPNKIKLIS MDLPMVSGDK IHCLDILFAF TKRVLGESGE
     MDALKQQMEE KFMMANPSKI SYEPITTTLR RKQEEVSAVI IQRAYRRHLL RRSMRQASFL
     YRHINSDGNI DVEDPPEKEG LIASMIKENY GHETEMTETL SSTSSPPSYD SVTRATSDIF
     QVVISDPRNT DQSEPFIHPD RDRESFL
//
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