ID W5MVX2_LEPOC Unreviewed; 692 AA.
AC W5MVX2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Upstream binding transcription factor, like {ECO:0000313|Ensembl:ENSLOCP00000012531.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012531.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01017477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MVX2; -.
DR STRING; 7918.ENSLOCP00000012531; -.
DR Ensembl; ENSLOCT00000012553.1; ENSLOCP00000012531.1; ENSLOCG00000010224.1.
DR eggNOG; KOG0381; Eukaryota.
DR GeneTree; ENSGT00940000165754; -.
DR HOGENOM; CLU_021068_1_0_1; -.
DR InParanoid; W5MVX2; -.
DR OMA; MAWNSME; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000010224; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006360; P:transcription by RNA polymerase I; IBA:GO_Central.
DR CDD; cd21998; HMG-box_UBF1_rpt1-like; 1.
DR CDD; cd21999; HMG-box_UBF1_rpt2; 1.
DR CDD; cd22000; HMG-box_UBF1_rpt3; 1.
DR CDD; cd22002; HMG-box_UBF1_rpt5; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 4.
DR InterPro; IPR029215; HMG_box_5.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR46318; UPSTREAM BINDING TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR46318:SF5; UPSTREAM-BINDING TRANSCRIPTION FACTOR,-LIKE; 1.
DR Pfam; PF00505; HMG_box; 2.
DR Pfam; PF09011; HMG_box_2; 1.
DR Pfam; PF14887; HMG_box_5; 1.
DR SMART; SM00398; HMG; 4.
DR SUPFAM; SSF47095; HMG-box; 4.
DR PROSITE; PS50118; HMG_BOX_2; 4.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 115..183
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 199..267
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 299..363
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 433..493
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 115..183
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 199..267
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 299..363
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 433..493
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..678
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 79660 MW; E039AB76CDAA1BD4 CRC64;
MNGSSSLSSP SQVECLKSDQ DGDEWSQEDC LTLLERIRSL LPEGDSLKYK TTESHIDWDK
VCFGAYSSDM CKQKWLKVST VVRKFRTMTE LIIEAMEKVK NPYKGKKLKT HPDFPKKPLT
PYFRFFMEKR AKYAKIHPEM SNLDLTKILS KKYKELPEKK KLKYMQDFQE EKESFKKNMA
RFKEEHPDLI QERKKSDIPE KPKTPQQLWY NHEKKTYMKL HPDVSQKELK EALRRQWSQL
SDKKRLKWIS KALELQKDYE DRMKAYLEAH PECNAEEHVK SVLTKAERQL KDKFDGRPTK
PPPNGYSLYC AELMVNMKDV PSTERMVLCS KRWKTMSQRE KDMFQKRCEQ KKKQYEIDLQ
RFLESLPEEE RDRVLTEEKL GGSRLGVGNA GSPHRAKSPS GKERYREADN VPDQRVQSLV
KDKHDGKKRV RLPETPKTAE EMWQQSVIGD YLAKYRNDRK KAQNAMESTW KAMEKKEKIP
WIKKAAEDQK RYEVYQYVGG LRHPMTQVPV PVPTLFSVTL FLNSVFSNFL VTVTQRAGFQ
WCGCTTGAAL TLEGTTASKV LSCSVLFQSL TPQERAVYKE FTSTKRRSSS KAGGPGAKVR
VPGKGKAVGA SARGLGAGGG RRALAYRSQE TSDSEEEEKT DSSDSEEEEE TSGSSESEED
EEEDEDDDED EDDQSEATSS SSTEESSDSD SD
//
