ID W5MVZ5_LEPOC Unreviewed; 3695 AA.
AC W5MVZ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Dystrophin {ECO:0000256|ARBA:ARBA00040142};
GN Name=DMD {ECO:0000313|Ensembl:ENSLOCP00000012554.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012554.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012554.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in anchoring the cytoskeleton to the plasma
CC membrane. {ECO:0000256|PIRNR:PIRNR002341}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR002341}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
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DR EMBL; AHAT01003553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01003559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000012577.1; ENSLOCP00000012554.1; ENSLOCG00000010164.1.
DR GeneTree; ENSGT00940000154342; -.
DR HOGENOM; CLU_000246_2_0_1; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000010164; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd21233; CH_DMD_rpt2; 1.
DR CDD; cd16246; EFh_DMD; 1.
DR CDD; cd00176; SPEC; 13.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 17.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035436; Dystrophin/utrophin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF25; DYSTROPHIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 13.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR PIRSF; PIRSF002341; Dystrophin/utrophin; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 21.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 19.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002341}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR002341}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002341};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002341};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002341};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|PIRNR:PIRNR002341};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|PIRNR:PIRNR002341};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 28..132
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 147..253
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 3065..3098
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 3318..3374
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 324..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3542..3563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3610..3695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 766..793
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1207..1312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1927..1954
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2513..2557
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2932..2969
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3506..3540
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3612..3683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3695 AA; 424590 MW; CFFD7F3E73600E78 CRC64;
MAEAGRPEEP VEDEFSGLIR TRTDEREDVQ KKTFTKWINS QFSKAGKPPI EDLFTDLRDG
RRLLELLEGL AGHELAKEKG FTRVHALNNV NRALQILQKN NVELVNIGGA DIVDGNHKLT
LGLIWSIILH WQVKDVMKNI MAGLQQTNSE KILLSWVRQS TRDYQQVNVV NFTNSWSDGL
AFNALIHSHR PDLFEWSSVL KQQSAIEKLD HAFSTAKQHL GIERLLDPED VATPHPDKKS
IIMYVTSLFQ VLPQQVTIEA IQEVETLPRH TKVTQEEHIQ IQHQHEQRYS QQITVSVAQG
HVRTPSPSPK PRYKSYAYTQ AAYVQSPDQK RRRCTAQPAE APEDKSASSP LMEAEGHLDS
YQSSLEEVLT WLLSAEDALQ SQGDISGDVE EVKEQFHTHE GFMMELTSHQ SSVGKVLQAG
SQLLSEGRLS DDEENEVREQ MNLLNTRWEH LRVTSMERQS KLHEVLMDLQ HQQLKQLSDW
LAVTESRVKK METQPLGPDL EDIKHQVEEH KLLQEDLEME QVRVNSLTHM VVVVDENSED
GATAALEEKL QHLGERWADI CRWTEERWIL LQEILLKWQH FTEEQCLFDA WLMEKEEAVN
KIQTSGFKEQ QEMVANLRKL AILKGDLEMK RQTMDKLCSL SQDLLSAVRN KDVAKKLEAR
LENFAQRWDS LVQTLERSSS QISQTVTTAQ TALSASTVME TVTMVTTREQ ILVKHAKEEI
PPPPPQKKRQ IVVDSELRKR FNVDTTELHS WMTRSEAVLQ NPEFSESRKE GNLSDLQERV
NAIEREKPEK HRKLQDASRS AQALVEQMVN EGLKADDIKQ ASEQLNSRWV EFCQLLEDRL
AWLAYHNKII AFYSHFQLLE QAVVAAENWL KSQQPLAPES ETVRVQLDKC KDEGSRLSAL
QPQVEMLKER GKELNAKEEA PMFLEADITA FTDRYNQVLA DLQAREQHLK NILESLPPAR
YRETVTSLLF WIQQSESRLV VPQFAVTEYQ AMEQRLKEIK ALQVSLQEQQ SGLNYLTSTM
DELCQKAPVE ISQKYRLEIE AILLRWKRLS AQLGEQSQKL EELMTKLQQF QNDTKTLKKW
MAEVDVFLNE EWPALGDSEA LEKQLEQCTA LVNDINTIQP SLNGINDVGQ TLRKEAEPAF
ASKLQKEISD LNIQWDNVCK QAYAKKSALK GGLDKTVSLR KDLSEMQEWI TQAEEDFLER
DFEYKTPEEL KKAVEELKRA KEEVQQKEVK VKLLTDSVNS FIAKAPPAAH EALKSELEVL
TSNYQRLCSR LNGKCKTLEE VWACWCELLS YLEAENRWLD ELELKLRNTE NIQGGAEEIS
EALDSLESSL RHPEDNRNQI RELAQTLTDG RVLDELINEK LETFNTRCEE LLQQAVRRQQ
MLEQSIQSAQ ETDKALRLIQ ESLATIDRHL SAYIADHVDA GQIPQEAQKI QSELSSHEIS
LDEMKKRNEG KALSERVQSQ INMTQKKLQE VSTKFRLFQK PANFDQRFLE CKTVLDEVKS
QLPVLAMRSV EQDVVQSQLD QCMKFYKSLS EVKSEVETVI KTGRQIVQRQ QTESPKELDE
RLTALKLQYN ELGAQVTEGK QELEKSLKLS RKLRKEVNAL TEWLAITDAE LTRRSSVEGM
PTHLDAEVAW AKAIQKDTEK HLQQLKNISD LAEALKAVLH GKENLVDDKV SLLNCNWIAV
TSRAEEWLNL LRDYQKQMEM FDQSIAQITA WIYRAEILLD ESEKQESQQE VLKGLKDELS
DIRLKVETVQ GQAEDLIKNR GDHCRVVVEP KLSELNQRFE AISQRIKIGK AFVTPRELEL
YHTEAQKWLE RLEAEVQEGD NLKEEDFQKD TEDNEEGAVK EFLEKGEKLH HRVPDEKKRE
EIRIKLNLLH AKYNTVKDLR SLRKKKALAI SPQWYQYKKQ SHDLLQWLDD IEKRVASLPD
PRDEERIKEI DAELEQKRED LNAVNRQAQS LSRDGAAKAV EPNLIQLNKR WQEIESKFAQ
FRRQNFAQIH SVYEETRVVK TEGPAAESPH VPSTYLAELR QLLHSVAEIE FLLNSPEYWA
GAYHDLVKQE DCLKDAKVSL TKLAGPVGNA QSRRSAVLQN ASPVEYSHIQ DSARQLDTNW
EKVNKLYKDR QVRYEKSAEK WRRFHADMKS LTQWLSEAER TLAETGAGSG SQDHSKAKER
LKELQNGIRH QQALVSSLNA TGEEIAQQST SEDAILFKER LTGVNVRWEE VCRQVAERRR
RSEEEKHIIS ELQEDLNEFL SWLDKAESIV SLELESGDEH QLKDSLEKIK LRVEELPSRK
KILKELNESG GHPHGSTALP SEEQRRLECD LKLANSRWTK VSRELPEKQK TTEALLKELV
QFQQHLNQLA FWASTTKDQL ELYLKVGLPG AFDTKETEDS VQAKQADVEA ILSRGHQLYK
DKPITQPIKV KLEDLSSDWK AIHILLTQFK GKPDPSAAVS CTTKIASIGQ TVTVVTQTLV
TKETVVSKLE MPSSLLMEVP ALADFNKAWA ELTDWLSLLD HMIRTQIVTV GDLEEINDMI
VKQKSTLQDL EQRRPQLENL ITAAQNLKNK TNNQEVRSII TDRIDKVQAQ WEEVQGALQG
RRLQLQDMLK DSSQWLEAKQ EAAPLLQRAT ARLESWKDIS YTVEALKRQN ADLKQFVKEL
RQWQINIDVA NDLARKLLRD YSADDTRKVN LVTEDMNNSW ANVNKKVGDR EAALEAALRL
LQQFYVDLEK FLSWLTEAET TANVLQDATH KEGILEDPHV VRELMKQWQD LQAEIEAHTE
TFHTLDDNGQ RILKSLEGSE DATLLQRRLD NMNVRWNELR KKSISIRSHL EASSEQWKRL
HLSLQELLAW LQLKNDELAQ QKPIGGDVPT VQKQLDTHRA FRRELKAKDL VVSNALDAVR
VFLAEQPAEG LARLQQEQRE VSPEERAQNI SRVLRKESED VRAGWEGLRG RAADWQRRLD
GALERLLELQ EAADELELKL RQAEMVKQSW QPVGDLLIDS LQDHIEKVKA FRAEVAPIKE
NVTQVNDLAS LFGPPDVQLS QFNLSRVEDL NTRWELLQVS IEERLKQLHE AHRDFGPTSQ
HFLSTSVQGP WERAISPNKV PYYINHQTQT TCWDHPKMTE LYQSLADLNN VRFSAYRTAM
KLRRLQKALC LDLLGLSAAC EAFEQHNLKQ NEQLMDIMQI INCLTTIYDR LEQEHNTLVN
VPVCVDMCLN WLLNVYDTGR TGKIRVLSFK TGIVSLCKAH LEDKYRYLFK QVASPTGFCD
QRRLGLLLHD SIQIPRQLGE VASFGGSNIE PSVRSCFQFA NNKPELEAAV FLDWMRLEPQ
SMVWLPVLHR VAAAETAKHQ AKCNICKECP IIGFRYRSLK HFNYDICQSC FFSGRIAKGH
KMQYPMVEYC TPTTSGEDVR DFAKVLKNKF RTKRYFAKHP RMGYLPVQTV LEGDNMETPV
TLINFWPVDY APTSSPQLSH DDTHSRIEHY ASRLAEMENR NGSYLNDSIS PNESIDDEHL
LIQHYCQSLN QESPLSQPRS PAQILISLEG EERGELEKVL SDLEEENKSL QAEYDRLKQA
HDHKGLSPLP SPPEMLPVSP QSPRDAELIA EAKLLRQHKG RLEARMQILE DHNKQLESQL
HRLRQLLEQP QAEAKVNGTT VSSPSTSSQR SDSSQPMLVR VVGSQTTDTM GEDDLLSPSQ
DPSTGLEEVM EQLNNSFPTN QGRSGPGKPV REVTM
//
