ID W5N101_LEPOC Unreviewed; 346 AA.
AC W5N101;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Gamma-aminobutyric acid receptor subunit beta-1-like {ECO:0000313|Ensembl:ENSLOCP00000014310.1};
GN Name=GABRB1 {ECO:0000313|Ensembl:ENSLOCP00000014310.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014310.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014310.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
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DR EMBL; AHAT01017914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N101; -.
DR STRING; 7918.ENSLOCP00000014310; -.
DR Ensembl; ENSLOCT00000014339.1; ENSLOCP00000014310.1; ENSLOCG00000011649.1.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000154245; -.
DR InParanoid; W5N101; -.
DR OMA; YWQGGSN; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000011649; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR002289; GABAAb_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF429; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01160; GABAARBETA.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Chloride channel {ECO:0000256|ARBA:ARBA00023173};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 81..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..80
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 88..341
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 346 AA; 39989 MW; 051506D5B549823B CRC64;
MDLRRYPLDE QNCTLEIESY GYTTDDIEFY WKGDGNSVTG VNNIELPQFS IMDYRTVSKK
VVFTTGSYPR LSLSFQLKRN IGYFILQTYM PSTLITILSW VSFWINYDAS AARVALGITT
VLTMTTISTH LRETLPKIPY VKAIDIYLMG CFVFVFLALL EYAFVNYIFF GRGPHLQKKA
AEKAAKANNE KGRLETNKVQ VQVILVVDIY FYNISEKVFR VQIDKAIKKE KVDAHGNILL
TTLEIRNEVS GSEVLTGLND PRATMFSYDS ASIQYRKPIT SRDIYGRSAA ERHMVHKKGR
LRRRASQLKI KIPDLTDVNA IDKWSRVIFP ITFTFFNVVY WLYYVH
//