ID   W5N2A0_LEPOC            Unreviewed;      1013 AA.
AC   W5N2A0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSLOCP00000014759.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014759.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000014759.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   EMBL; AHAT01017318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5N2A0; -.
DR   Ensembl; ENSLOCT00000014788.1; ENSLOCP00000014759.1; ENSLOCG00000011997.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   HOGENOM; CLU_010702_0_0_1; -.
DR   Proteomes; UP000018468; Linkage group LG5.
DR   Bgee; ENSLOCG00000011997; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        917..935
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          634..692
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
SQ   SEQUENCE   1013 AA;  114346 MW;  0896E6025D2002C1 CRC64;
     MLTKLFDFNL GSVTESSLWR STDYGTTYEK LNDKVGAKTI LNYLYVSPNN KRKIMLLTDP
     EIESSLLISS DEGATYQKYR LNFYILSLLF HPEQEDWILA YSHDQKLYSS VEFGRRWQLV
     HERVTPNRFY WSKTGLDKEP GLIHLETIVS EGQAQYVTCK LQNCTEANKG KPFPGYIDPN
     SLVVQDEYVF VQVSTGGQSV YYVSYKRETF TQMKLPKYTL PKDMHVISTD EYRVVAAVQE
     WNQNDTYNLY VSEARGVYFT LALENVMSSM GPEGNIMIDL YEVAGIKGMF LANKKLENQV
     KTYITYNKGR DWRLLQAPAT DLRGNDIQCV LPYCSLHLHL QVSDNPYTSG NIASKYSAPG
     IIVATGSIGS ELSNNNVSMF ITSDAGNTWR QIFDEEYSVL YLDQGGALVA IRHTPLPIRH
     LWLSFDEGRV WNKYSFTFTP LFVDGVLGEP GDETLIMTIF GHFSHRSEWQ LVKIDFRSIF
     NRRCTEADYQ TWHLHNQGEP CIMGVKRIYR KLKPTARCVM GKDYSVTMTS EPCLCTESDF
     ECDYGYERRG NGKCTPAFWF TPSSVSRICN SGKSFLNSTG YRKVVSNNCT AGVKELYTAR
     RQQCPNRPPR GLHLVTSEGK LTATLSTNVT FLIFLEEGDG SKTSIMVDFG DGNAISYSNV
     SSIEDGIKHV YKNVGIYKVS ATAENGLGSD SAVLYLHVTC QLEHIHLSAP FVAVKNKEVN
     LTAVLWPSQV GTVTYIWWFG NNTEEASVIL NVRVSEYEFS FRKPLTIQIQ QSAGNSLLQD
     RKTIAVHEYF RSQLLAFSSN LDDYNPDVAE WRQDISRVIK NSLVQVTDIG EEQLLVTVLP
     GLPTAAEFFL LPDKELTEGK PERNAAHLDQ LSEMLLSALN QNLIQFTLRP GVQVTVYAAH
     LSAAPLVDTS ESHSGSAMLM LLSVVFVGLA VFVIYKFKRK IPGINVYAQM QNEKEQEMIS
     PVSPIESTPN DTQRELVTSL ELLDKELDTR AIGCISPHAN IKISKEIPTY VNV
//