ID W5N2L1_LEPOC Unreviewed; 987 AA.
AC W5N2L1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Nuclear factor kappa B subunit 1 {ECO:0000313|Ensembl:ENSLOCP00000014870.1};
GN Name=NFKB1 {ECO:0000313|Ensembl:ENSLOCP00000014870.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014870.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AHAT01017793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01017794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015200704.1; XM_015345218.1.
DR RefSeq; XP_015200705.1; XM_015345219.1.
DR RefSeq; XP_015200706.1; XM_015345220.1.
DR RefSeq; XP_015200707.1; XM_015345221.1.
DR AlphaFoldDB; W5N2L1; -.
DR STRING; 7918.ENSLOCP00000014870; -.
DR Ensembl; ENSLOCT00000014899.1; ENSLOCP00000014870.1; ENSLOCG00000012080.1.
DR GeneID; 102693746; -.
DR KEGG; loc:102693746; -.
DR CTD; 4790; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000158625; -.
DR InParanoid; W5N2L1; -.
DR OMA; GCSPNQQ; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000012080; Expressed in bone element and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0038061; P:non-canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 41..248
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 586..618
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 619..651
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 655..687
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 689..722
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 723..755
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 369..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 106936 MW; 9FEBCD490F9584EC CRC64;
MAEEDPYLQG GIFDMETFTP LMGMETFNFT AMPPTNSLRV ADGPYLQIIE QPKQRGFRFR
YGCEGPSHGG LPGASSEKNR KSYPQVKICN YQGPARVVVQ LVTFSKNVNL HAHSLVGKQC
DKGICVADQQ PKDTSISFPN LGILHVTKKN VNKTLEERMT EAYRMGYNYG ISIHPEIDCL
QSEGRIPREL TEHQKSLITN AATSQAKEMD LSVVRLMFTA FLPDSDGGFT RRLEPVISDP
IYDSKAPNAS NLKIVRMDRT AGCVTGGEEV YLLCDKVQKD DIQVRFYEDD ETGLAWEAYG
DFSPTDVHRQ FAIVFKTPKY RDLNLQKPTS VFVQLKRKSD NETSEPKPFT YHPQVIDKEE
VQRKRQKTLP NFQDFGPPGA GGGMYRGGGP GTGGGPSTGG GQCNFQGYQG YNNFGGGYPF
SHGPGGPGAG MKHASKGPTD DAEDDSDSDT DEDPATAGIV QICGQQASEE IKLPPKVEQS
SSTEDSSPTE DPASAEEEEI TADLLFGEKA MQLAQRHAEA LFNYAVTGDV KMLLAVLRPL
LAVQDENGDT GLHLGVIHSR TDAVKSLAEV ISALPGDDVL SMRNDLYQTP LHLAVITKQA
EAVEALLKAG ANMSLTDRHG NTALHLAAKE GEGKILNLLL EHKDAAELID LPNAAGFHAI
HLAVLANSIL CLRQLIEFGA NVDACEQSSG RTALHLAVEL ENVSLAGCLL LEGNAHVDAC
TYNGSTALHI AAGKGSMKLT ALLMAAGADP HKENSEPLYD VDDECHLEEE EEDEGFVPGT
TPLDMAMSSE IYDLLNGKQY QPDSKTVVSL PQGDMKHLDE QTKLELCKVL EQPANNWEAL
AQNLGLGILS SAFRLSPSPA KTLLDSYKVS GGTMKELLEG LKAMGNDKAV DIVQKAMSSE
REDTSGPVST QVTHQQTGAL LSQHLQGLEN YSQDESSVCD SGVETSFRKL SLLSSESLSS
SQEQAEQAGD HKLPTASPHS YVVKGEV
//
