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Database: UniProt
Entry: W5N427_LEPOC
LinkDB: W5N427_LEPOC
Original site: W5N427_LEPOC 
ID   W5N427_LEPOC            Unreviewed;       843 AA.
AC   W5N427;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015386, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000015386, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000015386}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000015386}.
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DR   EMBL; AHAT01023082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01023083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01023084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000015415; ENSLOCP00000015386; ENSLOCG00000012492.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    450    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    663       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    775    799       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   843 AA;  96347 MW;  7D40A06AEA675B1C CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPIM DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EMADPELLEE SSSLLDPSEV GRGAPLRLGL FCSALSNQNA
     VPAEQQSWSF LTGHNFLFLR QCELLLCRKC LQPKTHGDQV HKSVFIIFFQ GDQLKNRVKK
     ICEGFRASLY PCPETPQERK EMAAGVNTRI DDLQMVLNQT EDHRQRVLQA AAKTVRVWFI
     KVRKMKAIYH TLNLCNIDVT QKCLIAEVWC PVTDLDSIQF ALRRGTERSG STVPSILNRM
     QTKQTPPTYN KTNKLTSGFQ NIVDAYGIGS YREINPAPYT IITFPFLFAV MFGDCGHGAL
     MTCFAVWLIL RESRILSQKS DNEMFNMIFS GRYIILLMGV FSIYTGLIYN DCFSKSLNMF
     GSGWSVRPMF TTANWTTEML KGNPVLQLDP AIKGVFNGPY PLGIDPIWNI ATNKLTFLNS
     FKMKMSVILG IIHMLFGVTL SLLNHLYFKK PLNIFLGFIP EIIFMTSLFG YLVILIFIKW
     GAYDAATSKS APSLLIHFIN MFLFNYNDKS NKMLYTGQVG MQCFLVVLAL LCVPWMLVVK
     PLVLRRQYLR RKHLGTHNFG GIRVGNGPTE EDAEIIQHDQ LSTHSEDENE PSDDEVFDFT
     DTVVHQAIHT IEYCLGCISN TASYLRLWAL SLAHAQLSEV LWTMVMHIGL SVRSYGGFFG
     LLFIFAAFAT LTVAILLVME GLSAFLHALR LHWVEFQNKF YTGLGFKFVP FSFDSILEGR
     FDD
//
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