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Database: UniProt
Entry: W5N4D0_LEPOC
LinkDB: W5N4D0_LEPOC
Original site: W5N4D0_LEPOC 
ID   W5N4D0_LEPOC            Unreviewed;      4856 AA.
AC   W5N4D0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   22-NOV-2017, entry version 25.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSLOCP00000015489};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015489, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000015489, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000015489}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000015489}.
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DR   EMBL; AHAT01019042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01019043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000015518; ENSLOCP00000015489; ENSLOCG00000012545.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4167   4183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4396   4416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4465   4484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4657   4678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4737   4760       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    780       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      996   1192       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1445       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3907   3942       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4856 AA;  551559 MW;  02A2D0B334E2A6C6 CRC64;
     DDEVVLQCVA NIQKEHRKFC LAAEGLGNRL CYLEPTSEAK YVPPDLCICN FVLEQSLSVR
     ALQEMLANTV ENASEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLSFDV
     GLQEDATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVS SERYLHLSFS NGNIQVDASF
     MQTLWNVHPT CSGSSVEEGY LLGGHVMRLF HGHDESLTIP GSDQSDEQRR IVNYETGGAG
     ARARSLWRLE PLRISWSGSH IRWGQPFRVR HLTTGHYLAL TEDRGLVLQD REKCDTKSTA
     FCFRASKEKL ESSPKRDIEG MGAAEIKYGD SICFVMHVAS GLWLSYQAPD AKSARLGPLK
     RRAILHQEGH MDDGLTLQRC QHEESQAARI IRNTSKLFSQ FISDLDSLSG KNRTSVALPI
     EEVLQTLNDL ITYFQPPEEE LEHEEKQNKL RSLKNRQNLF KDEGMLTLVS NCIDRLNVYN
     SAAHFGEYAG EEAGAAWKDI LNLLYELLAA LIRGNRNNCT QFSDNLDWLV SKLDRLESSS
     GILEVLHCIL IESPEALNII QKGHIKSIIS LLDKHGRNYK ILDVLCSLCV CNGVAVRANQ
     NLICDNLLPR RDLLLQTRLV NDVQSMRPNI FLGVSEGSAQ YKKWYYELMI DQVDHFVTSE
     PSHLRVGWAT TKGYAPYPGG GEGWGGNGVG DDLYSFGFDG LHLWSGRIPR AVASINQHLL
     SSDDVVSCCL DLGVPSISFR INGQPVQGMF ENFNTDGLFF PVVSFSAGVK VRFLLGGRHG
     DFKFLPPSGY APCYEALLPK EKMRVEPVKE YKRDFEGVRD LLGTTQFLSQ ASFIPTPVET
     SQIVMPPHLE KVRDKLAENI HELWGMNKIE LGWSYGKVRD DNKRQHPCLV DFSKLPETEK
     NYNLQMSTET LKTLLALGCH VVQVNVNAEE DLKKMKLPKN YMMSNGYKPA PLDLSEVKLI
     PAQEVLVDKL AENAHNVWAK DRIKQGWTYG IQQDLKSKRN PRLVPYALLD ERTKKSNRDS
     LREAIRTLIG YGYNIEPPDQ EGAGQTVERL SIDKIRFFRV EKTYAVKTGK WYFEFEAVTG
     GDMRVGWARS GCRPDMELGL DDQAFVFDGF RGHRLHQGSW FFGRSWRAGD VVGCMINLED
     KSMIFTLNGE ILITNKGSEL CFADFEVEDG FIPVCSLGLS QIGRMNLGKD ASTFKYYTMC
     GLQEGFEPFA VNMNREVTMW FSKRLPTFVN VPKNHPHIEA TRIDGTVDSP PCLKVTHRTF
     GTQNSNADMV YCRLSMPVEF HSTFKNTGIS DAEGMHDDES LKAKQSYYHS VRIFGGQDPS
     CVWVGWVTPD YHYYSHNFDL SRNRTVTVTL GDERGRVHES VKRSNCYMVW GGDVINTSHT
     SSRTNVDLEI GCLIDLATGL VSFTANGKDM GTSYQVEPNT KLFPAVFVRP TSSKLFQFEL
     GKVKNFMPLS SAIFKSEHKN PIPQCPPRLD IQTITPVLWS RMPNTFLKVE TARVSERHGW
     VVQCLEPLQM QAVHIPEENR CVDILELSEQ EDLRMFHYHT LRLYCALCAL GNNRVAHALC
     SHVDQSQLLY TIDNQYLSGK LREGFYDLLI SMHLETAKEA RLMMNNEFII PITDETRSIR
     LFPDESKKHS LPGVGLSTSL KPRLNFSPPC LITTKGEQQL HSPQIPLDIL KEKAISMLTE
     AVQGGGHHIR DPVGGSVEFQ FVPILKLIGT LLIMGVLSND NVKQILLLID PNVFGERKEE
     EPEETKEKEE VTSNEEKAVE AGEEEAKDSK QPMKGLLEKR LPESVKRQMC ELLHYFCDCE
     LRNRIEAIVS FSDSYVSKLQ QNQKFRYNEL MQALNMSAAV TAKKTREFRS PPQEQINMLL
     QFSAGDDCPC PEEIREELYD FHDDLLLHCG IPIEEEEEEA QDTSIKGRLL SLVYKIKGAP
     QKQEAEPTEE TQSAPSNLKE LISQTMVSWA QECHIQDPEL VRVMFSLLRR QYDSIGELLR
     SMRKSYTISA ISVQDTINLL ASLGQIRSLL SVRMGREEEM LMINGLGDIM NNKVFYQHPN
     LMRVLGMHET VMEVMVNVLG GDKSQDSAWI KILMYCCFAF LSFCFSFKTS DILFHNKIHS
     SNNAVQGWFL ASPAMRGSTP LDVAAASVMD NNGLALALEE PDLDKVVTYL AACGLQSCPM
     LLAKGYPDIG WNPIEGERYL SFLRFAVFVN AESVAENSSV VVKLLIRRPE CFGPGLRGEG
     GNGLLAAMKE AIMISENPAL DVPPALQGVH RDVSVDGEEE EEVVHMGNAI MSFYSALIDL
     LGRCAPEMHL INKGKGEALR IRAILRSLVP TEDLVGIISI PLKMPTVNKD GTVTEPDMSA
     SFCPDHKAPM VLFLDRVYGI EDQSFLLHLL EVGFLPDLRA SASLDTEALS TTETALALNR
     YICSAVLPVL TRCASQFEGT EHYAPLIDST LHTIYRLSKG RSLTKAQRDA IEECLLSICR
     YLRPSMLQQL LRRLVFDVPL LNEYCKMPLR LLTNHYEQSW KYYCLPSGLG SYGMASEEEV
     LLTKKLFWGI FESLSQKKYD PELFKMAMPC LSAISGALPP DYVDSSITTT LEKQASVDAQ
     GNFDPKPIST ANISLPEKLE YIANKYAEHS HDKWASEKLP SGWKYGETLD EKLKTHPLLR
     PYKSLTEKER EIYRWPVKES IKSMLAMGWN IERTKEGEVM FQQRESEKLR KISQSSQGNG
     YSPCPVDMTN VVLSRELQAM VEVVAENYHN IWAKKKKIEL GSRGGGGHPL LVPYDTLTAK
     EKARDREKAQ ELFRFLQING YAITRGLKDM EQDASSMEKR FAYKFLKKLL KYVDSAQEFI
     AHLEAMVSSG KADKSPHEQE IKFFAKVLLP LIDQYFKNHS LYFLSSPIKT LSSSGYASNK
     EKEMVTSLFC KLAALVRHRI SLFGSDSATM VSCLHILART LDTRTVMKSG SELVKAGLRT
     FFESAAEDLE KTLENLKLGK FTHSRTQMKG VSQNINYTTV ALLPILTSLF EHITQHHFGI
     DLILDDVQVS CYRILCSLYS LGTGKNIYVE RQRPALGECL ATLAGAMPVA FLEPHLNMHN
     PHSVFNTKSP RERAILGMPD TVEEMCPEMP RLDGLMKDIN DMAESGARYT EMPHVIEVIL
     PMLCNYLSYW WERGTENTES SSPCCTMVTS EHLSIILGNI LKILNNNLGI DEASWMKRIA
     VYAQPIISKA RADLLKTHFL PTLEKLKKKT VKVVAEEEML KADSKGDTQE AELLILDEFA
     VLCRDLYSFY PMLIRYVDNN RRSRWLKEPD ADSNELFRMV AEIFILWCKS HNFKREEQNF
     VVQNEINNLS FLTGENKTKM SKSMHLKTGG QDQERKRTKR RGEFYSIQTS LIVAALKKML
     PIGLNMCTPG DQELISLAKY RYSLKDTDEE VIDHLRQNLH LQEKSEDPAV RWQLNLYKDV
     VVKSEEPPDP ERTVSRVQRI SAAVFHLEQN KVEQPLRSKK AVWHKLLSKQ RKRAVVACFR
     MAPLYNLPRH RSINLFLQGY QRFWIETEEY SFEEKLVQDL ARPQKKTEED EEEEAEKQPD
     PLHQLILHFS HNALTERSSL EEDPLYIAYA DMMAKSCQGE EEDEEEGKEK TFEEKEMEKQ
     KTLYQQARLH DRGAAEMVLQ MISASKGQLG PMVTYTLKLG IAILNGGNVV VQQKMLDYLK
     EKRDAGFFKS LSGLMQSCSI NSVLDLNAFE RQNKAEGLGM VTEEGSLNVR EQGEKVLQND
     EFTKDLFRFL QLLCEGHNND FQNFLRTQTG NTTTVNIIIS TVDYLLRLQE SISDFYWYYS
     GKEVMDEPGQ RNFSKALAVA KQIFNSLTEY IQDPHYFSFA HSGIWDAVVG FLHVFANMQM
     KLSQDSSQIE LLKELLDLQQ DMVVMMLSLL EGNVVNGTIG KQMVDTLVES SSNVEMILKF
     FDMFLKLKDL TSSDAFKEYD PDGKGVISKK EFQKAMESQK QYTQSEIEFL LSCAEADEND
     MFNYVEFVER FHEPAKDIGF NVAVLLTNLS EHMPHDSRLG AFLELAESVL NYFEPYLGRI
     EIMGGAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGESEKM ELFVNFCEDT
     IFEMQLASQI SEPDVTERSD EDEEEPHNIL EELETEEEDS ASLESSSAFA IACVSMKKNF
     AHFMQLLTFR NLKKQYKKFK KMSMKEMIKV FFSFFWMIFV GLFRFVYTLV WGLIQIVWSS
     MFGGGLVEGA KNMKVTDILG NMPDPTQFGI HGDVLEAEKA EMSESTASSD LVQLAKGEKG
     EPDLMTELIG ITTKKEGKHG PEPGLGDISE IIGTDAPSTL ASAVRQKKLA QAGDMTKDTE
     TDIKAEPEKA DTEDGEKKDK VKEDEAPEPV VEEERKVRRR RHGQKKEESE AFMATFCAGL
     EIYQTKILNY LARNFYNLRL LALFVAFAIN FILLFYKVTE DPYDEEESDE DSDLWNGDDE
     EDDEGGVVYF VLQESTGYMA PTLRFLAIIH TIISLLCVIG YYCLKVPLVV FKREKEIARK
     LEFDGLYITE QPSDDDIKGQ WDRLVINTPS FPNNYWDKFV KRKVINKYGD LYGAERIGEL
     LGLDKSALDF NPTEEAVAKE ATLVSWLSSI DTKYHIWKLG VVFTDNSFLY LAWYTTMSIL
     GHYNNFFFAA HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK
     FYNKSEDEDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDPYEM YRIVFDITFF
     FFVIVILLAI IQGLIIDAFG ELRDQQEQVR EDMETKCFIC GIGNDYFDTT PHGFETHTLQ
     EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWDF FPAGDCFRKQ YEDQLG
//
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