ID W5N5X3_LEPOC Unreviewed; 1046 AA.
AC W5N5X3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Klotho beta {ECO:0000313|Ensembl:ENSLOCP00000016032.1};
GN Name=KLB {ECO:0000313|Ensembl:ENSLOCP00000016032.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016032.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016032.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01001979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N5X3; -.
DR STRING; 7918.ENSLOCP00000016032; -.
DR Ensembl; ENSLOCT00000016062.1; ENSLOCP00000016032.1; ENSLOCG00000013013.1.
DR eggNOG; KOG0626; Eukaryota.
DR GeneTree; ENSGT00940000157489; -.
DR InParanoid; W5N5X3; -.
DR OMA; ARMKVTH; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000013013; Expressed in intestine and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353:SF68; BETA-KLOTHO; 1.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR Pfam; PF00232; Glyco_hydro_1; 2.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 988..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1046 AA; 118139 MW; 2F68DC9519F2EC01 CRC64;
RSSDGPSSAR LSSRVLSLSS APAVMLVSLG LGWIRGAVVC LPGDGRAVWR AQSSSSPVDA
SQLFLHGTFP RDFLWGAGSA AFPSEGAWDQ DGKGPSIWDH FTRSQQAPGS GTSSDSYRLW
EQDVELLKHL GVRTYSFSIS WPRLFPNGTG GAPNLPGVEH YNLLIDRLKQ EGIEPVVTLY
HWDLPLALQQ LHSGWHSDAL VDDFEGYAAF CFQSFGDRVK YWVTMHNPYA VAWHGYGTGV
HAPGERGNLT AVFAVAHNLI KAHAKAWHTY DRRFRKLQHG QVSIALGSHW IEPEGGKASP
FNVEKCQESM EAVLGWFAEP IYGQGDYPTL LKNSTHGLLP AFTAEEKDNI KGTADFFAFS
FGPNSLRLVH SSVRFGQHVS LSLRQVLNWI KLQYNNPRIL ILENGWFSDT SVTTEDTVAI
YVMKKFINQV LQAMLHDGVQ VLGYTLWSLV DGFEWNYGYS VRRGLFYVDP NSKDKARIPK
TSAAFYKQVI KDGGFPGREG DEAVQGQFPC DFHWGVSDSV LQVRFSPSSP QFLDPNLYLW
NVTGDGALRP ISGIRMETRG PQCTDFLAIP KHLQLVQMSG ADHYRFALNW SLLLPSGDLS
AVNREAVRYY RCVVTELRKR GVRTMLTLYY PTFHHQLGLP APLHKAGGWL NRTTIEAFRD
YAALCFRELG PWVKHWITLN EPNRLSHAYN ASGSDAYTAA HHLLLAHAAA WRLYDREYRA
RQGGRVSLSL HADWAEPANP YLDSHASAAR RFLLFELAYF LDPLLGPGDY PAPLRRYLRE
KTGAGLSRSA LPDVTPEERE AFRGALDFVA LNHFTTRLVT HRRANGSRNL DDRDCELMSD
ITFPASQLGL SVVPWGVRRV LAWVRERYGE EVEIYITANG VDERSRDNDV VRQYYMRSYL
QEVLKAHQLD HVNVKGYYVW KLQDKHIPQF GLFNSQLFQS TARSSVNTYR ELIANRGFPA
LGQLGVSCEE EEGRSCSVCA FVLERKPFFF FGICLFVTLS LLTMVLAVAR RRRRKPKRRS
RARSRWERAT LLQLGSNVKQ SCFRKN
//
