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Database: UniProt
Entry: W5N6K3_LEPOC
LinkDB: W5N6K3_LEPOC
Original site: W5N6K3_LEPOC 
ID   W5N6K3_LEPOC            Unreviewed;      1696 AA.
AC   W5N6K3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   10-MAY-2017, entry version 23.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016262, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000016262, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000016262}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000016262}.
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DR   EMBL; AHAT01028928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000016292; ENSLOCP00000016262; ENSLOCG00000013195.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1696       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004868880.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    264    291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    474    492       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    504    527       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    539    563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    584    612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    671    697       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    910    928       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    949    965       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1026   1052       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1149   1173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1232   1250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1262   1280       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1312       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1377       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1453   1476       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    298       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      475    701       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      711    903       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      908   1181       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1231   1486       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      288    322       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1696 AA;  192650 MW;  8289E97A9B1004BC CRC64;
     MFIMITILAN CVFMTMNNPP SWSKNVEYAF TGIYTFEALV KVLARGFCIG DFTFLRDPWN
     WLDFSVITMA YATEFIDLGN VSALRTFRVL RALKTITVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLRQKCVRWP PLMNDTWIVD DNHRNSTSDY MNDTSVFDWN
     EYVNNNDNFY FLEGSLDALL CGNSSDAGRC PEGYTCMKAG NNPNYGYTSY DTFGWAFLAL
     FRLMTQDFWE NLFQLTLRAA GKTYMIFFVV IIFLGSFYLI NLILAVVAMA YAEQNEATMA
     EAKEKEEEFQ RILEQLKKQE AGLHGSAGAH ASHSSLGSHK GRKKDSVSEQ EFADDEHSLG
     EDGGALRDCN GRIVPRVIID RVSSDEESVA EEEKKEKENL KSRPSIGHLE DPGLQKRRAS
     AVSVLTNAME ELEEAQQKCP PWWYKFANKV LKWDCCPLWI KFKHAVHFVV MDPFVDLGIT
     ICIVLNTLFM AMEHYPMSQD FEHILSVGNL VFTGIFTAEM VFKIIALDPY YYFQTGWNIF
     DSIIVTLSLV ELGLANVQGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL
     VLAIIVFIFA VVGMQLFGKS YKDCVCKIAS DCELPRWHMN DFFHSFLIVF RILCGEWIET
     MWDCMEVAGQ AMCLIVFMMV MVIGNLVVLN LFLALLLSSF SADNLSGGDE DGEMNNLQIA
     IGRITRGIDF MKKSVLNLVF RLLGRKPKEE DNDPKKENFV LNHMETGEET KTDLKMLDGV
     SASEANTADE VDRSAFVTNP QVTVSVPIAK GESDFENPDE EDFSSECEPD DTKKKKLGDE
     GSCSTVDFKP PEPEVEEKLE ETPESDDPEA CFTEGCVRRF PCLTVDITQG RGKSWWNLRK
     TCFTIVEHNW FETFIIFMIL LSSGALAFED IYIEQRRAIK IILEYADKVF TFVFVIEMLL
     KWVAYGFKTY FTNAWCWLDF LIVDVSLISL TANLLGYSEL GPIKSLRTLR ALRPLRALSR
     FEGMRVVVNA LVGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKYYRCINT TTEEVIDMSV
     VNNKSDCLAL MWTNEVRWVN MKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSREIEDQ
     PSYEINIYMY LYFVIFIIFG AFFTLNLFIG VIIDNFNQQK KKFGGKDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPQNKI QGAVFDFVSR QFFDIFIMVL ICLNMVTMMV ETDDQSPAKE
     EILNWINLVF IVIFTGECIL KMFALRYYFF TIGWNIFDFV VVILSIVGIM LADIIEKYFV
     SPTLFRVIRL ARIGRVLRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA
     NFAYVKKQAG IDDIFNFETF GNSIICLFQI TTSAGWDGLL LPILNSGPPD CDPDIEHPGS
     DFKGNCGNPA MGIMFFCSYI IISFLIVVNM YIAIILENFN VATEESSEPL CEDDFEMFYE
     TWEKFDPDAT QFIEYCRLSD FCDTLQEPLK IAKPNKIKLI SLDLPMVPGD KIHCLDILFA
     LTKEVLGDSG EMDALKESME EKFMAANPSK VSYEPITTTL KRKQEEVAAS IIQRAYRRHL
     LKRSVKHASY MFRHHDSEQE RGEEAPEKEG MIAEKMNENY GGKPAVEVTS DVVLRSAPRT
     AAGPSASGGN IRESIV
//
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