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Database: UniProt
Entry: W5N6K8_LEPOC
LinkDB: W5N6K8_LEPOC
Original site: W5N6K8_LEPOC 
ID   W5N6K8_LEPOC            Unreviewed;      1811 AA.
AC   W5N6K8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016267, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000016267, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000016267}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000016267}.
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DR   EMBL; AHAT01028928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000016297; ENSLOCP00000016267; ENSLOCG00000013195.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     98    117       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    220    240       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    365    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    576    594       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    606    629       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    641    665       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    686    714       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    773    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1024   1042       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1063   1079       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1140   1166       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1287       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1347   1365       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1377   1395       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1402   1427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1464   1492       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1568   1591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       98    399       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      577    803       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      813   1017       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1022   1296       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1346   1601       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      389    423       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1811 AA;  205697 MW;  F870367A91853742 CRC64;
     MANLLPPTGP EVFRRFTPES LAEIERRVEQ EAAEKQKKQH VEVAEEDLPK PASDLEAGKP
     LPFIYGDPPP EILNDPIEDL DPYYRAKKTF IVISRGKTIY SMFIMITILA NCVFMTMNNP
     PSWSKNVEYA FTGIYTFEAL VKVLARGFCI GDFTFLRDPW NWLDFSVITM AYATEFIDLG
     NVSALRTFRV LRALKTITVI PGLKTIVGAL IQSVKKLSDV MILTVFCLSV FALIGLQLFM
     GNLRQKCVRW PPLMNDTWIV DDNHRNSTSD YMNDTSVFDW NEYVNNNDNF YFLEGSLDAL
     LCGNSSDAGR CPEGYTCMKA GNNPNYGYTS YDTFGWAFLA LFRLMTQDFW ENLFQLTLRA
     AGKTYMIFFV VIIFLGSFYL INLILAVVAM AYAEQNEATM AEAKEKEEEF QRILEQLKKQ
     EAGLHGSAGA HASHSSLGSH KGRKKDSVSE QEFADDEHSL GEDGGALRDC NGRIVPRVII
     DRVSSDEESV AEEEKKEKEN LKSRPSIGHL EDPGLQKRRA SAVSVLTNAM EEELEEAQQK
     CPPWWYKFAN KVLKWDCCPL WIKFKHAVHF VVMDPFVDLG ITICIVLNTL FMAMEHYPMS
     QDFEHILSVG NLVFTGIFTA EMVFKIIALD PYYYFQTGWN IFDSIIVTLS LVELGLANVQ
     GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG
     KSYKDCVCKI ASDCELPRWH MNDFFHSFLI VFRILCGEWI ETMWDCMEVA GQAMCLIVFM
     MVMVIGNLVV LNLFLALLLS SFSADNLSGG DEDGEMNNLQ IAIGRITRGI DFMKKSVLNL
     VFRLLGRKPK EEDNDPKKEN FVLNHMETGE ETKTDLKMLD GVSASEANTA DEVDRSAFVT
     NPQVTVSVPI AKGESDFENP DEEDFSSECE PDDTKKVRNV PVLFAIADKK LGDEGSCSTV
     DFKPPEPEVE EKLEETPESD DPEACFTEGC VRRFPCLTVD ITQGRGKSWW NLRKTCFTIV
     EHNWFETFII FMILLSSGAL AFEDIYIEQR RAIKIILEYA DKVFTFVFVI EMLLKWVAYG
     FKTYFTNAWC WLDFLIVDVS LISLTANLLG YSELGPIKSL RTLRALRPLR ALSRFEGMRV
     VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKYYR CINTTTEEVI DMSVVNNKSD
     CLALMWTNEV RWVNMKVNFD NVGLGYLSLL QVATFKGWMD IMYAAVDSRE IEDQPSYEIN
     IYMYLYFVIF IIFGAFFTLN LFIGVIIDNF NQQKKKYFGG KDIFMTEEQK KYYNAMKKLG
     SKKPQKPIPR PQNKIQGAVF DFVSRQFFDI FIMVLICLNM VTMMVETDDQ SPAKEEILNW
     INLVFIVIFT GECILKMFAL RYYFFTIGWN IFDFVVVILS IVGIMLADII EKYFVSPTLF
     RVIRLARIGR VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYS IFGMANFAYV
     KKQAGIDDIF NFETFGNSII CLFQITTSAG WDGLLLPILN SGPPDCDPDI EHPGSDFKGN
     CGNPAMGIMF FCSYIIISFL IVVNMYIAII LENFNVATEE SSEPLCEDDF EMFYETWEKF
     DPDATQFIEY CRLSDFCDTL QEPLKIAKPN KIKLISLDLP MVPGDKIHCL DILFALTKEV
     LGDSGEMDAL KESMEEKFMA ANPSKVSYEP ITTTLKRKQE EVAASIIQRA YRRHLLKRSV
     KHASYMFRHH DSEQERGEEA PEKEGMIAEK MNENYGGKPA VEVTSDVVLR SAPRTAAGPS
     ASGGNIRESI V
//
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