ID W5N7F2_LEPOC Unreviewed; 311 AA.
AC W5N7F2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Homeobox B1 {ECO:0000313|Ensembl:ENSLOCP00000016561.1};
GN Name=HOXB1 {ECO:0000313|Ensembl:ENSLOCP00000016561.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016561.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; AHAT01031028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006638417.1; XM_006638354.2.
DR AlphaFoldDB; W5N7F2; -.
DR STRING; 7918.ENSLOCP00000016561; -.
DR Ensembl; ENSLOCT00000016589.1; ENSLOCP00000016561.1; ENSLOCG00000013432.1.
DR GeneID; 102691038; -.
DR KEGG; loc:102691038; -.
DR CTD; 30337; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159503; -.
DR HOGENOM; CLU_058839_1_0_1; -.
DR InParanoid; W5N7F2; -.
DR OMA; HHEQHTH; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000018468; Linkage group LG15.
DR Bgee; ENSLOCG00000013432; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 213..273
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 215..274
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 61..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 33452 MW; C42AC9F03DFDD6CD CRC64;
MDSTRMNSFL EYTICNRGMS AYSPKAGYPH LDQGIASPFP ASAGTPSDSF HGDARFFVGG
GAPAAPVQHQ HQNPNYSHPY PNTGPAAYGS QAPNQEYGHQ FFIGPEQEGV YFQSSGYSAP
NVGPSLGALA GGYCGTPGAV PSTQYQHPAC AGPELQQGGY LQNSYPGLSP TQGGEKELRC
PAEQTPSGQT FEWMKVKRNP PKTAKVAEYG AAGPQNTIRT NFTTKQLTEL EKEFHFNKYL
TRARRVEIAA TLELNETQVK IWFQNRRMKQ KKREKEGLAP AAGAGTSREP GEHSDNSVST
SPDASPSSAA S
//
