ID W5N8E7_LEPOC Unreviewed; 1862 AA.
AC W5N8E7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Tight junction protein 1 {ECO:0000313|Ensembl:ENSLOCP00000016906.1};
GN Name=TJP1 {ECO:0000313|Ensembl:ENSLOCP00000016906.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016906.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016906.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AHAT01024855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01024856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01024857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000016936.1; ENSLOCP00000016906.1; ENSLOCG00000013706.1.
DR GeneTree; ENSGT00940000155164; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000013706; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12026; SH3_ZO-1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005418; ZO-1.
DR InterPro; IPR035597; ZO-1_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01598; ZONOCCLUDNS1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 94..181
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 262..340
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 501..582
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 596..664
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 770..871
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 1728..1862
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..944
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1340
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1532..1550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1672
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1862 AA; 207381 MW; 835B9042B9F43D81 CRC64;
MSPHNQEPFQ PRECGAIQPP PPPPATAAGE TSCDPRVTPS SDTSNAAASS GSQGKPSLRR
IKGRIHRSKS LDSIELLDSN SAAMEETVIW EQHTVTLHRA PGFGFGIAIS GGRDNPHFQS
GETSIVISDV LKGGPAEGLL QENDRVVMVN AVSMDNVEHA YAVQQLRKSG KNAKITIRRK
RKVQIPVSRP ERETMSEHED DSYEDEVYEE RSARSGPSAY SGGRRSERSG GRRDRSASRE
RSLSPRSDRR SVASNLPPRP AKVTLVKSRK NEEYGLRLAS HIFVKDISPE SLAARDGNIQ
EGDVVLKING TVTENLSLID AKKLIERSKG KLKMVVQRDE RATLLNIPDL DDSVASANAS
DRDADISEIH SLASDHSNRS HDRNRSSRSR SPDRRSEPSD HSRHSPQQIS NGRFEHNLRS
RDEERISKPG AISTPIKIAE EAVISKPVEQ PVVKEEKQIP PLPEPKPVYA QPGQPDVDLP
VSPSDAPIPN AAHDDGMLRP SMKLVKFKKG ESVGLRLAGG NDVGIFVAGV LEDSPAAKEG
LEEGDQILRV NNVDFANIIR EEAVLFLLDL PRGEEVTILA QKKKDVYRRI VESDVGDSFY
IRTHFEYEKE SPYGLSFNKG EVFRVVDTLY NGKLGSWLAI RIGKNHQEVE RGIIPNKNRA
EQLSSVQYTL PKTAGGDRAD FWRFRGLRSS KRNLRKSRED LSAQPVQTKF PAYERVVLRE
AGFLRPVVIF GPIADVAREK LAREEPEIFE LAKSEPRDAG TDQRSSGIIR LHTIKQIIDR
DKHAVLDITP NAVDRLNYAQ WYPIVVFLNP DSKQGVKNMR TRLCPESRKS ARKLYERALK
LRKNNHHLFT TTINMNSMND GWYGALKETV QQQQNQLVWV SEGKADGAPD DDLDLHDDRL
SYLSAPGSEY SMYSTDSRHT SDYEDTDTEG GAYTDQELDE TLNDEVGPPA EPAITRSSEP
VRDDPSVLQD PQGYPSYQHS VQADVPNRID PAGFKMPAPQ QKTEAVPAMP NLPHQPEPIA
VVTAPSAVDH SVYAPEEPPA APLSSYSPQA GPLRKPAPEL AQAMPNDPHQ SGLPITEPKM
FKKDLYGMEE PARQNHGMKQ PVVGHPMQRY DKEQPLNYEP QPQYQDEQPY RDYDHPPYRY
DSAGNYMEPK SRSYDSHLHY ENRVPHYDDQ WSHYDQNPPQ AYTARTPYEN QHPQSYEPRP
PYEESAEREY SPTQPRYEES PTVGYDSRPR YEPPAKSYGK PLQPRYEEQP PVGYEARPRY
EPEPHAFPPP VSRSPEPKQY YDPQVRPYAQ GPQRPYKLGQ YEPPLNAEPP LPPPPQVQPK
SEVPPVSSKP LPPPPAADQD DDPAMKPQSV LTRVKMFENK RSASVDRARE AGDSAVIKPA
EAAPKPVIGP GPVPKANSLS HLDQEKTSYS RGPEPQKPQV KAPEDIVRSN HYDPDEDEEY
YRKQLSYFDR RTFDNKPAPQ QSVSRLLDPV KPAQPNYSSR RKKNNYRCTN TSTSCMCMGE
AVEKVSPAEK RYEPVPQITP PASQYGQPVQ TRPAPSVPPA VLPKPLAPEV NPLPLEALST
PKCKPEPPSL QTAPTSLRPS NREDTVQSSY LPQKSFPEKA PVNGTDQPSK PVATSYNRFT
PKPYTSSARP FERKFESPKF NHNLLPNDTQ QKPEPLVKPV STAPPPPSKP QSSPQSAEQD
SGLDTFSRPV ENRPKYQQNN IGAVPKAIPV SPSALEDDEE DEGHTVVATA RGVFNSNGGV
LSSIETGVSI IIPQGAIPEG VEQEIYFKVC RDNSILPPLD KEKGETLLSP LVMCGPHGLK
FLKPVELRLP HCASMTPDGW SFALKSSDSS SGDPKSWQNK SLPGDPNYLV GANCVSVLID
HF
//
