ID W5NA03_LEPOC Unreviewed; 1656 AA.
AC W5NA03;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSLOCP00000017462.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017462.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017462.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01024787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628835.1; XM_006628772.2.
DR STRING; 7918.ENSLOCP00000017462; -.
DR Ensembl; ENSLOCT00000017493.1; ENSLOCP00000017462.1; ENSLOCG00000014170.1.
DR GeneID; 102698473; -.
DR KEGG; loc:102698473; -.
DR CTD; 8826; -.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR InParanoid; W5NA03; -.
DR OMA; KGVLVHW; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000014170; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010761; P:fibroblast migration; IBA:GO_Central.
DR GO; GO:1903479; P:mitotic actomyosin contractile ring assembly actin filament organization; IBA:GO_Central.
DR CDD; cd21274; CH_IQGAP1; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 42..157
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 679..712
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1004..1237
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1656 AA; 188772 MW; E52A5B7BF5FB1E57 CRC64;
MSTSDEADGL RPRYGSVLDG VERLTAEEMD ERRQQNMAYE YLCHLEEAKQ WMEACLDEEL
PPTTELEEGL RNGVYLAKLG NFFAPRVVSV KKIYDREQTR YRATGLHFRH TDNVIQWLNA
MTEIGLPKIF YPETTDIYDR KNMPRCIYCI HALSLYLFKL GLAPQIQDLY GKVDFTEEEI
NNMKSELEKY GIQMPAFSKI GGILANELSV DEAALHAAVI AINDAIDHGV PEGTMAAMRN
PNAMLVNIDE GSAQDYQDRL YLAKQEKVAS ARKRMAGENS EEERDVYEEL LTQAEIQGNI
KKVNLGNALS STEQAILSGD EDRLYDALRS QALGLRGLQP QNKEWYLKQL DSDRKNKEQS
YPGELLTKEE LQSGVDLANE DAASYQRLLV AVQRINTAIR AGVAEDTVSE LMKPDAQLPQ
VYPTAADLYQ RELATLQQQS SEGSLTHPEL MVAVEMLSSV VLINRSLDAG DRAAVWRQLE
SPVTGLSNVE DECAQRYIDE LMRMKMAVRA ETNEFLSWND IQACIDQVNT AVQEEHERIM
AIGQINEALE EGDVQKTLAA LQHPAAKLSD VDPPVAQHYY DKLLEARREK AHETQDPSAV
LWLDEIQDTV HTSNKDTQDA LLFSQAILAI NEAVEQGDAP QTLAALRCPS SGLYGITPEC
AQTYQNDLAN AKQDKKTEGD NGSEWMKNWV KGGHNYYFNL KTREGSWDEP PNFIQNNTQL
SKEEIQSVVS GVTSAYNREQ LWLANESLIS KLQARCRGFL VRDGLKKRLS YLKSQDPAIT
RIQAHWRGHK QRKKFQDRKQ YLKDHSEEAV KIQSKVRMYQ ARKKYQDRLK YFRDHMAEIV
KIQAFIRANK ARDDYKTLIS AEDPPMAVVR KFVHLLDHSD QDFQEELELM RLREEVVTNI
RSNQQLENDL NLMDIKIGLL VKNKITLQEV VSHSKKLSKK NKDQLSDMLM MNKQKGGLKA
LSKEKRVKLE AYQYLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY
LLLKLFKTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILSPVVKEIM
DDKTLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ AMAHEEVRTR LDASIKNMRT
VTDKFLSAII VSVDKIPYGM RFIAKVLKDT LHEKFPDATE DELLKIVGNL LYYRYMNPAI
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLNP INEYLSNSYQ
KFRRFLLAAC DVPSLEDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH
NDPIHELLED LGEVPTIESL IGEGTLPASD PNKEMLGKTE VSLTLTNKFD VPDSENAEMD
AKTLLLNTKR LIVDVIRFQP GETLTEILET PAAAEQEAEY QRAMQRRAIR DAKTPEKMKQ
KKPVQDDTLT LEGKKEKIQG NLKRLGELGK ISPEKRYQDL INDIAKDIRN QRRYRQRRKA
ELVKLQQTNA ALNSKTSFFN EQIDYYNQYI KTCMDNLASK GKVSKKPGEV KAKKSKQVSQ
KYTAARLHEK GVLIAIEELQ ANQFKNVIFE ISPSEEVGDF DVKAKFMGVQ IETVVLHYQD
LLQLQYEGVA VMKLFDKATI NVNLLIFLLN KKFYGK
//
