ID W5NA34_LEPOC Unreviewed; 1043 AA.
AC W5NA34;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Toll like receptor 9 {ECO:0000313|Ensembl:ENSLOCP00000017493.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017493.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017493.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AHAT01015075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015203532.1; XM_015348046.1.
DR AlphaFoldDB; W5NA34; -.
DR STRING; 7918.ENSLOCP00000017493; -.
DR Ensembl; ENSLOCT00000017524.1; ENSLOCP00000017493.1; ENSLOCG00000014202.1.
DR GeneID; 107077431; -.
DR KEGG; loc:107077431; -.
DR CTD; 54106; -.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163875; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; W5NA34; -.
DR OMA; NFLPCCS; -.
DR OrthoDB; 4603490at2759; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000014202; Expressed in intestine and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0038187; F:pattern recognition receptor activity; IBA:GO_Central.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IBA:GO_Central.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1043
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869057"
FT TRANSMEM 825..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 877..1021
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1043 AA; 120006 MW; 3CB9413908F97B4E CRC64;
MEPMALLRSV LLLLCICHLL PLARTAFLKF FPCDTDPKSS RVDCSKRGLT QVPLINSQSV
VSLNLDENRI WLVENNAFTG LPNLQYLSMS WNCLPSKLKS PGSPPCQMVI EPNAFVNLKK
LRHLFLAGNS LTKVPKLTAG LQYLSIEINK IFNITSPLGA PNLRQLNLNK NCFFANPCNQ
SFYIKEDVLK EMQHLQNLTL GFNNLTVVPS GLPWSLESLD LRENKISEIK EADFANLTRL
WNLNLEWNCQ RCDHAAQPCF PCPHNASIRL HPKAFQSQGN LNSLSLRGNS LKNLSESLFV
PLTSLSRLDL SDNLLAYVIR NGTFFKHLKN VTSLNLLYNY QPLKTFANLY LSKYMEEMTL
LEDLYISGYF FLELAPRGLR PLLNLRHLQS LDFRMNFINK VNMSIFSHMK ALKKVVLSQN
MLAFSPSCKQ GIDQLDNQDQ SVGERAPLVL QDLGRNQKDS VAKWDQCHQV PEMWMFQKNF
CQGHLFFDLS QNNILSIKED IFLGIEKAVC LDLSSNYISQ PLDGRQFSPL KNLSYLNLAH
NRIDLYYPNA FKELATTLKV LDLTHNEYHF LMKGMGHRFE FLRHLMSLEV LSLSENNIGI
RISTRLHSSS LKYLYFSGNR LEIMWDSKFD QYLHFFTDLT SLIFLDISRN QLTSFPPEAL
CNLPKTLESL KVNDNHLTFF PWNHLIVLRN LNYLNLSYNS LSSLPKEMIN FGPILKVLDL
SHNKINWIPE VFFLNATALR CILLNNNKLK LLSSQNLPSP LLQNLSHLTL HANPFTCTCD
SSWFTEFLKT TNITIPHLID LRCEFPESQL GEHVLSMDPR SCQEIYGSIG FLCTFLLTSA
FLMVSLLKKL YGWDLWYSIQ VFWAGKRGYS LLPGGESQYD AFVVFDTRNA AVTDWVYNDL
RVNLEDKGRQ RFKLCFEERD WVPGVACIQN LHNSVYSSKK TVFVLASGSS VSGILRQAFF
MVQQRLLDEK VDVVVLVLLD KVFYKSRYLQ MRKILCRKSV LTWPMNPHAH QHFWNSMKTI
LASDNCKYYD SNVNESFLIN NLV
//
