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Database: UniProt
Entry: W5NAB3_LEPOC
LinkDB: W5NAB3_LEPOC
Original site: W5NAB3_LEPOC 
ID   W5NAB3_LEPOC            Unreviewed;      4944 AA.
AC   W5NAB3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSLOCP00000017572};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017572, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000017572, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000017572}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLOCP00000017572}.
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DR   EMBL; AHAT01029452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01029461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000017604; ENSLOCP00000017572; ENSLOCG00000014248.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; QNANTDM; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4252   4272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4491   4511       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4566   4588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4689   4708       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4746   4766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4825   4848       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1802   1831       {ECO:0000256|SAM:Coils}.
FT   COILED     3586   3613       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4944 AA;  560654 MW;  4A13C7724712F755 CRC64;
     REGEKGGEKI AFLNQDDEVV LQCTATILKE QIKLCLACEG FGNRLCFLES TSNAQHIDLI
     LPFHTCALKG SWNPTCVVEN TGSCSEIPEA VDLDKWSSQG GGHRTLLYGH AILLRHSHSS
     MYLSCLTTSR SLTDKLAFDV GLQEDATGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYA SGDLMVDASF MQTLWNMNPV CSGCELAEGY LTGGHVLRLF HGHMDECLAI
     AASDQAEEQR RQAHYEGGAV CSHARSLWRL EPLRISWSGS HMKCGQPFRV RHVTTGRYLG
     LDEEKGLMVV DPERANTKMS AFCFRASKEK LEVAPKRDVE GMGTPEIKYG ESMCFVQHVS
     TGLWLTYAAV DAKSARLGPL KRKAILHQEG HMDDALSLSR SQHEESQAAR MIYSTTGLFR
     QFIKNPLSPD LKTPPECHPV RLELPERVQD TSRTVHGYFH VQDRHLDGSD ISVTEQLDLG
     NNRQNLFQEE GMIALVLECI DRLNVYNTAA HFSEMAGEEA AESWKEIVNL LYELLASLIR
     GNRANCALFS DNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD
     KHGRNHKVLD VLCSLCVCNG VAVRSNQNLI TENLLPGRDL LLQTNIINYV TSVRPNIFLG
     TCEGSTQYRK WYFEVMVDYV EPFVTAQAMH LRVGWALTEG YSPYPGGGEG WGSNGVGDDL
     YSYGFDGLHL WSGELCWQGV KRRGDNDESN DHDEFEQICM DSEPNADILY MARKLNIKTF
     FVSNPLPLLT FSLPQFRDDN KKLHPCLVEF QRLPEPERNY NLQMSGETLK TLLALGCHVG
     MADEKAEENL KKIKLPKTYM MSSGYKPAPL DLSHVKLTPA QNTLVDRLAE NGHNVWARDR
     VRQGWTYSIV QDIMNKRNPR LVPYNLLDER TKKTNRDSVC EAVRTLIGYG YNIEPPDQES
     SEGPLCYLSV FESIVYSLQC SVCGSWSICS FVFSSVCHSV QCSWSLXQAF KDIEIGEGEG
     AGVQGHRDRR GGGEGEGESR AGVGYSCGSR PSRTSRSERV RSRVLVWEQA FKDIEIGEGF
     IPVCSLGLSQ VGRINLGQDV SSLRYFTICG LQEGFEPFAI NMKRDITMWF SKSLPQFNPV
     PTDHHVEVSR VDGTVESPPC LKVTHRTFGS QNANTDMFFM RLSMPVEFHE TFRVPAGTTP
     LTHPLTNPEE EVQEVDPDSE FEQLKKSASR KEAEGTEKEP SQPREIPGEN EKDAASEKGK
     KRGAFSRAER TDFHPILLFS SARLHHSCSL LVSLSYHFPF ILAVNITLSL WRLSRYLPKP
     LSHHFLTLSL SLCHLLFSLT TLLSLSLTRL FPLSVSRASM KRSNCYMVWA GEFSNSSQQT
     RITQEDLVIG CLVDLATGLM TFTANGKEIN TFYQVEPNTK LFPAVFSLPS SQNMLQFELG
     KLKNIMPISA AMFRSERKNP VPQCPPRLDI QMLTPVVWSR MPNQFLEPES ARVSERHGWM
     VECTEPLIMM ALHIPEENRC IDILELSERL DLLKFHHHTL KLYCAVCALG NNRVAHALCS
     HVDESQLLYT IENTYLPGPL RSGYYDLLIS MHLESAKRSR LMMNNEFIVP MTEETRSIKL
     YPDVEKKHGL PGVGLSTCLR PKLHFSPTNF VGTDPDLYTL SPVIPLQVLK TKAINMLTEA
     VQDGGQHTRD PVGGSVEFQF VPVLKLISTL LIMGVFEDDD VRHILKMIEP NVFAGGASGE
     VEGEGEGEGG EGEGEQPTTK EEGEEMKEKA EGGTPEEEEE LEEEELEDEG MGAEGEEEEG
     EVEEEEGKGE KADEEKEEDM EEKELEASEY EPKEEEDGLE EGLLQMKLPE SVKLQMCNLL
     QYFCDCELRH RVEAIISFSD RFINLLQSNQ RQRYNELMMA FTMSAAETAR KTREFRSPPQ
     EQINMLLNFK HCLDDEDCPV PDEIRDEMQE FHNDLLSHCG QSGNTLIDIQ FSEVCLTLPL
     NLRGRFLSLV HKIKSLRRRK QEEEPEPEEE AKPSTLQELI SHTMVHWAQE SFVQNPELVR
     LMFSLLHRQY DGLGELIRAV PKAYIINAVS VHDTMDLLEC LGQIRSLLIV QMGPEEERLM
     IQSIGNIMNN KVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPRM VTNCCRFLCY
     FCRISRQNQR SMFDHLSYLL QNSGIGLGMR GSTPLDVAAA SVIDNNELAL ALQEQDLEKV
     VTYLAGCGLQ SCPMLLSKGY PDIGWNPMGG ERYLDFLRFA VFVNGESVEE NANVVVRLLI
     RRPECFGPAL RGEGGNGLLA AIEEAIKISE DPARDGPTVK KDRRFPMFGG EEQHEENRVH
     LGNAIMSFYA ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLPVQIP
     SFGKDGNIVE PKMSASFVPD HKAPMVLFLD RVYGIDNQDF LLHLLEVGFL PDMRAAASLD
     TAAFSTTEMA LALNRYLCQA VLPLLTKCAP LFAGTEHRAI MIDSMLHTIY RLSRGRSLTK
     AQRDVIEDCL MSLCKYLRPS MLQHLLRRLV FDVPILNEYA KMPLKLLTNH YERCWKYYCL
     PNGWANYGVS SEEELHLTRK LFWGIFESLA HKKFDPELFK IAMPCICAIA GAIPPDYVDA
     SYSSKTEKKA SVDAEGNFDP KPVETTNTII PEKLDGFINK YAEYTHDKWA FEKIQNNWTY
     GEILDENAKT HPMLRPYKTF SEKDKEIYRW PIKESIKAMI AWEWTLEKAR EGEEEKTEKK
     KTRKISQTVQ ATYDPSHGYN PQPIEISGMA LSRELQAMAE QLAENYHNTW GRKKKLELQA
     KGGGTHPLLV PYDTLTAKEK ARDREKAHEL LKFLQLNGYA VTRGLKDMEL DTSSIEKRFA
     YGFLQKLLKW MDIAQEFIAH LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFKNHCLY
     FLSTPAKVLG SGSHSSNKEK EMIASIFCKL AALVRHRVSL FGTDAPAVVN CMHILARSLD
     ARTVMKSGPE IVKAGLRSFF ESAAEDIEKT VENLKLGKVS QSRTQVKGVS QNISYTTVAL
     LPVLTSLFEH LAQHQFGDDF ILDDLQVSCY RIMCSIYSLG TTKNPYVERQ RPALGECLAR
     LAAAMPVAFL EPHLNEHNQF SVYTTKTPRE RAILGLPNQV QDLCPDIPEL DVLMKEIGDL
     AESGARYTEM PHVIEITLPM LCNYLPRWWE RGPENFPDQE GRLCTDVTAE PLNQLLGNIM
     KIVVNNLGIE EASWMKRLAV FAQPIVNRAR PDMLKSHFIP TMEKLKKRSG KVVAEEDQLR
     LEGKTESDEA EGIIRDEFSV LCRDLYALYP LLIRYVDNNR ARWLTYPDSD AEELFRMVGE
     VFIFWSKSHN FKREEQNFVV MNEINNMSFL TADSKSKMSK AGDGQSGGSD QERTKKKRRG
     DRYSVQTSLI VAALKKMLPI GLNMCSPADQ ELINVAKTRY ALKDTDEEVR EFLQNNLHLQ
     GKVDNPSMRW QMALYKEMSG KAEDAEDPEK VVKRVQEVAA VLYHIEVMEH PFKSKKAVWH
     KLLSKQRRRA VVACFRMTPL YNLPRHRASN MFLEGFKRTW IETEGYSFED RMIDDLSKSM
     EQEEEEEEET ETKPDPLHQL ILHFSRTALT EKSKLDVDYL YMSYADIMAK SCHIGEEDEE
     GEEEKGGEEL SFEEKEMEKQ RLLYQQARLH NRGASEMVLQ MISACKAPGE TGMMVSSTLK
     LGISILNGGN NEVQQKMLDY LKEKKEVGFF QSVQALMQTC SVLDLNAFER QNKAEGLGMV
     SEEGTSEKVM ADDEFTCDLF RFLQLLCEGH NNDFQNYLRT QTGNTTTINI IICTVDYLLR
     LQESISDFYW YYSGKDTIDE PGKRNFSKAM NVAKQVFNSL TEYIQGPCTG NQQSLAHSRL
     WDAVVGFLHV FAHMMMKLAQ QRLKKDSSQI GLLKELLDLQ KDMVVMLLSL LEGNVVNGTI
     ARQMVDMLVE SSSNVEMILK FFDMFLKLKD IVASDAFRDY VTDPRGLISK KDFQKAMDSQ
     KQYSPSEIQF LLSCSEADEN EMINFEEFAN RFQEPAKDIG FNIAVLLTNL SEHVPHDTRL
     QNFLEQAESV LNYFRPFLGR IEIMGASKRI ERIYFEISEA NRTQWEMPQV KESKRQFIFD
     VVNEGGESEK MELFVNFCED TIFEMQIASQ ISETEEEGRE EVDEEDVGGE VVGGGGGAGE
     GGEANGESGH EPESSSAFAD FVNSVFHFLG MFTFRNLRRQ YRKLKKMTLK EMVVGLASLF
     WTLLMGILHF IYSVCKGFFL LIWHTLFGGG LVEGAKNITV TELLASMPDP TQDEVHGDLP
     ADSGGSEELD SGAAGDLLET GKGEEAEEEA QDMFGDRKEG GRMASIDAPG GLGDIGETTP
     VEPPTPEGTP LAKRKMLRLL WLSGEEQEPE PEPQVIEEPP PEPEKADAEN GEKAEKEEEE
     AAPEEEEPQK KKKKKMKREQ KQTGSQDGFE FWNELEIQRI KFLNYLSRNF YNLRFLALFV
     AFALNFILLF YRVSDSPPGE DEFEGSGLFD DEGEGSGFEE GGGEEEEEEG PVYYFLEEST
     GYMEPALAFL AIIHTLISFL CIIGYNCLKV PLVIFKREKE LARKLEFDGL YITEQPEDDD
     IKGQWDRLVL NTPSFPSNYW DKFVKRKVLE KYGDIYGRER IAELLGMDLA SLDISAQTQE
     KKSEPDNSVX TVFQSFLYLV WYLVMSLLGH YNNFFFACHL LDIAMGVKTL RTILSSVTHN
     GKQLMMTVGL LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA
     GGGIGDEIED PAGDEYELYR VVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED
     METKCFICGI GSDYFDTTPH GFETHTMEEH NLANYMFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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