ID W5NAS8_LEPOC Unreviewed; 651 AA.
AC W5NAS8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Synapsin-1 {ECO:0000256|ARBA:ARBA00017852};
DE AltName: Full=Synapsin I {ECO:0000256|ARBA:ARBA00029646};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017737.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017737.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle {ECO:0000256|ARBA:ARBA00004234}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Presynapse
CC {ECO:0000256|ARBA:ARBA00034106}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the synapsin family.
CC {ECO:0000256|ARBA:ARBA00008243}.
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DR EMBL; AHAT01006708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NAS8; -.
DR STRING; 7918.ENSLOCP00000017737; -.
DR Ensembl; ENSLOCT00000017769.1; ENSLOCP00000017737.1; ENSLOCG00000014401.1.
DR eggNOG; KOG3895; Eukaryota.
DR GeneTree; ENSGT00940000165688; -.
DR HOGENOM; CLU_010582_3_0_1; -.
DR InParanoid; W5NAS8; -.
DR OMA; QWITEVS; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000014401; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR001359; Synapsin.
DR InterPro; IPR020898; Synapsin_ATP-bd_dom.
DR InterPro; IPR019735; Synapsin_CS.
DR InterPro; IPR019736; Synapsin_P_site.
DR InterPro; IPR020897; Synapsin_pre-ATP-grasp_dom.
DR PANTHER; PTHR10841; SYNAPSIN; 1.
DR PANTHER; PTHR10841:SF24; SYNAPSIN-1; 1.
DR Pfam; PF02078; Synapsin; 1.
DR Pfam; PF02750; Synapsin_C; 1.
DR Pfam; PF10581; Synapsin_N; 1.
DR PRINTS; PR01368; SYNAPSIN.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS00415; SYNAPSIN_1; 1.
DR PROSITE; PS00416; SYNAPSIN_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 86..187
FT /note="Synapsin pre-ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF02078"
FT DOMAIN 189..391
FT /note="Synapsin ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF02750"
FT REGION 15..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..446
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 70840 MW; F13027407F55EFB2 CRC64;
MNYLRRRLSD SNFMSNLPNG YMSDLQRPDP PQPSPAVSPG PPERRQSSSQ SAGSGFFSSI
SNAVKQTTAA AAATFSEATD RATGPSRAKI LLVIDDQQTD WVKFFKGKKV HGEFDIKVEQ
ASFSEINLVA HATGSYSVDI EALRNGNKIT KSFRPDFVLV RQHAFSMAKN GDFRNIVIGL
QYAGLPSVNS LHTVFNFCDK PWVFAQMTRL YKKMGPEDFP LIEQIYYPNH REMITTPRFP
VVVKMGHAHS GMGKVKVDNH YDFQDIASVV ALTKTYATSE PFIDAKYDVR IQKIGNNYKA
YMRTSISGNW KTNTGSAMLE QVAMSDRYRL WVDSCSEIFG GLDICAVEAL HGKDGKDYII
EVVGCSMPLI GEHQDEDRAL IADLVLNKMN QTVSRTPIPS PLRPTAAAQP AQPPVPQAVS
PQPAQAQPRP APGPQTGPPA QQRPAPQGQP PIDECQNTGS RSPPSSPAVP QAAPRSLPRE
PRGQGSPQRS QGGSPQTQRQ QPPPQQQQQQ QQRPAGAPGP KPGGGQPQQR PPQQRQQGQS
TRQPGQQGRP VAPTTQQPRA SAQGQGGPLG LAGPGGRPPM QQKPQPPQKP SQDHPSMGMG
GPPQLNKSQS LTNAFNIPET SAAPRSSLSQ DEVKAETIRN LRKSFASLFS D
//
