ID W5NBG1_LEPOC Unreviewed; 1038 AA.
AC W5NBG1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 {ECO:0000313|Ensembl:ENSLOCP00000017970.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017970.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017970.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR EMBL; AHAT01015616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NBG1; -.
DR STRING; 7918.ENSLOCP00000017970; -.
DR Ensembl; ENSLOCT00000018002.1; ENSLOCP00000017970.1; ENSLOCG00000014591.1.
DR eggNOG; KOG0385; Eukaryota.
DR GeneTree; ENSGT00940000157297; -.
DR HOGENOM; CLU_000315_0_2_1; -.
DR InParanoid; W5NBG1; -.
DR OMA; VHDYQFF; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000014591; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR GO; GO:0021999; P:neural plate anterior/posterior regionalization; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060319; P:primitive erythrocyte differentiation; IEA:Ensembl.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; ISW-1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 157..322
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 452..603
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 824..876
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1038
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 121491 MW; 648E20B35236876A CRC64;
MSDEEIPSTS REPEPDSEEK EDPPFQLKPP PKLVTKVEAD VDPEYEEKRK TDRANRFEFL
LKQTELFAHF IQPAAQKSPT SPLKVKLGRP RMKKDEKQNL LSVGDNRHRR TEQEEDEELL
SESRKTSNVL VRFEESPSYV KNGALRDYQI RGLNWMISLY ENGINGILAD EMGLGKTLQT
IALLGYLKHY RNIPGPHMVL VPKSTLHNWM NEFKRWVPTL RAVCLIGDKD ARAAFIRDVM
MPGEWDVCVT SYEMVIREKS VFKKFNWRYL VIDEAHRIKN EKSKLSEIVR EFKTTNRLLL
TGTPLQNNLH ELWSLLNFLL PDVFNSADDF DSWFDTNNCL GDQKLVERLH AVLRPFLLRR
IKAEVEKSLP PKKEVKIYLG LSKMQREWYT KILMKDIDIL NSAGKMDKMR LLNILMQLRK
CCNHPYLFDG AEPGPPYTTD THLVTNSGKM VVLDKLLPKV KEQGSRVLIF SQMTRVLDIL
EDYCMWRGYE YCRLDGNTPH EEREEAIEAY NAPNSTKFIF MLSTRAGGLG INLATADVVI
LYDSDWNPQV DLQAMDRAHR IGQTKTVRVF RLITDNTVEE RIVERAEMKL RLDSIVIQQG
RLIDQQSNKL AKDEMLQMIR HGATHVFASK DSELTDEDIN TILERGAKKT AEMNERLEKL
GESSLRNFTV DTETSLYNFE GEDYREKQKV FILFVLYNTN SLLIQFYNLS MMEWIEPPKR
ERKANYAVDA YFREALRVSE PRAPKAPRPP KQPNIQDFQF FPPRLFELLE KEILYYRKTI
GYKVPKNPEL SNATQVQKEE QRKIDEAGPL TAEETEEKEK LLTQGFTSWN KRDFNQFIKA
NEKYGRDDID NIAREVEGKT PEEVIEYSAV FWERCNELQD IEKIMAQIER GEARIQRRIS
IKKALDAKIA RYKAPFHQLR IQYGTNKGKN YTEEEDRFLI CMLHKMGFDK ENVYEELRQC
VRNAPQFRFD WFIKSRTAME LQRRCNTLIS LIEKENMEIE EKERAEKKKR APKAQTAQKR
KTDTLSDTAG RKDKKLKS
//