ID W5NBN0_LEPOC Unreviewed; 522 AA.
AC W5NBN0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018039.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018039.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01023774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01023782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NBN0; -.
DR Ensembl; ENSLOCT00000018071.1; ENSLOCP00000018039.1; ENSLOCG00000014652.1.
DR GeneTree; ENSGT00940000166445; -.
DR HOGENOM; CLU_012574_1_1_1; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000014652; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF411; SUSHI, NIDOGEN AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 291..327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 367..403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..440
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 442..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..516
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 355..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 393..402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 409..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 430..439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 468..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 506..515
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 522 AA; 55290 MW; 02B254BAE9403002 CRC64;
SLSAALLPLQ VLQAVGVFEL QIEQLQNTNG LLLGGGCCDG GGGGGAGGRC PQADQCDTFL
RACLKEYQVR VSPTGPCTFG AGSTGVLGGN SFSLRHRTPG EQVGRIGIPF KYAWPKSFSL
VLEVLDHDND TVGAVLLSQT ELLENVVAQC CLCPGLTWAS GSYSDLPDMW VLGRQGCLSQ
YCSSNLRCVG NRGCQGRGEV TGHSEAQQAG CSVCSEFSSC FCLIPAVCRQ GCHLAHGYCS
TPGECKCHYG WEGPLCDRCV TFPGCVHGSC TEPWMCVCDT NWGGLLCDKA VEHACLSNPC
ANGGTCVEEA EGFYCVCPEG WTGPSCTTGV NECQPNPCSQ GGTCRQLQHG FECLCPPQWT
GRTCQLDTNE CDRGVCVHAV ACHNLIGGYF CDCQPGWTGQ DCDITNHTCQ GKCQNGAVCE
ESLTGYRCQC PPGFTGSYCQ TRASHCDSAP CLNGGHCAEE EETPQCHCPL GYSGKHCEEV
LDLCNPNPCQ QGAPCQSTEG GYLCACPQGY EGKECLSLKD TC
//