ID W5NCR8_LEPOC Unreviewed; 1445 AA.
AC W5NCR8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Neogenin 1 {ECO:0000313|Ensembl:ENSLOCP00000018427.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018427.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018427.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
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DR EMBL; AHAT01004875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015199138.1; XM_015343652.1.
DR Ensembl; ENSLOCT00000018459.1; ENSLOCP00000018427.1; ENSLOCG00000014953.1.
DR GeneID; 102687746; -.
DR CTD; 4756; -.
DR GeneTree; ENSGT00940000156684; -.
DR HOGENOM; CLU_004256_0_0_1; -.
DR OrthoDB; 5398621at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000014953; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05722; IgI_1_Neogenin_like; 1.
DR CDD; cd05723; IgI_4_Neogenin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF14; NEOGENIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1445
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867571"
FT TRANSMEM 1091..1115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..224
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 229..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..411
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 447..540
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 546..636
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 641..735
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 742..839
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 844..940
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 945..1042
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 422..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 157361 MW; 86B0B75420A018E0 CRC64;
MAEWGARLLL SLSCLTFLRS AAVARHAEKD SGARHFTPFW FSEEPSDTLA VRGSPALLNC
SAQSDGPVRL EWKKDGTFLN LASDDRRQLL PDGSLLVGSV VHSKHNKPDE GVYQCVASVD
SLGTISSRTA RLAVAGQPRF TSQPEAASVH QGDSEVMSCE VNSDLVPFTR WELNREPVEL
NKRVIQLPSG ALVISNASES DTGLYRCVVE NVGPVKTSEE AELQVLLEPE ADRRLEFLRQ
PVPVTKVIGQ SVLLPCVVTG YPLPTVRWMV GDKLIEEREG KFETVGGGSL QIVNLTEEDA
GIYSCLADNG NETIEAQAEL TMQAPPQFLK KPANIYAYES MDIVFECEVM GTPPPTVKWV
KNGDAVIPSD YFKIIKEHNL QVLGLVKSDE GFYQCLAEND AGNVQASAQL IILERDVAIP
TPPPTSLTSA TTDHVAPGSG GGPTPSAPRD VVASLVSTRF IKLTWRPPAE PHGDDITYSV
FYSLEGTSRE RIENTTRPGE LQVTIQSLMP DTKYSFRVAA HNRNGLGESS TPLRVATQPE
VQVPGPAPNL QAIATSPTSI AVSWEVPLTG NGEIQAYKLY YMEKGTDSEQ DIDVGGLSYT
MNGLKKYTKY NFRVVAYNKH GPGVSTADVE AQTLSDVPSA PPQNFSLEVR NSKGIMVQWQ
PPPPGTHNGE IIGYKIRYRK GARKSEISET TVGVLLSQLI EGLERGTEYT FRVAAMTGNG
TGPPTEWATA ETFESDLDET RVPDIPSSLH VRPLVTSIVV SWTPPENQDI VVRGYTIGYG
IGSPHAQTIK VDYKQRYYTI ENLDPSSHYV ITLKAFNNIG EGIPVYESAA TRPLSVPDPS
PMMPPVGVQA SVLSHDTIKV TWADSSLPKN QKITDARYYS VRWKTNIPAN TKFKTANTTN
LSYMVTGLKP NTLYEFSVKV TKGRRTSTWS MTAHGTTFET IPSSPPKDVT VVSKEGRPRT
IIVNWQPPSE ANGKITGYII YYSTEVNAEV HDWVIEPVVG NRLTHQIQDL TLDTPYYFKI
QARNSKGMGP MSEAVQFRTP KAESSDKMAN DQASSPVKPG GRPTSPDHGV GSPHGKTGFS
GSPTSSLDSS ILLIIIISVG AFTIIIVVVV AVICTRRTTS QQKKKRAACK SANGSHKYKG
NSKDLKPPDL WIHHERLELK PIDKSPEPNP VMTDTPIPRT SQDITPVDSA ADNTIHQRRS
SCRGHESEDS MSTLAGRRGM RPKMMMPFDA QPPQPVISAH PIHSLDNHHH HYHSGSLASP
TRSHLHHQIN PRPLATPISH VDRAHSAESV RNTPSADPLP VPVQPACAVD HPEPDSGASF
LSSAPEEESY NPPTAHVRPT HPLKSFAVPA VPTPGTSFES PALPSTPLLT QTGPASQVHS
VKTASIGTLG RTRSPMPVIV PSAPDVPETS KMLEDVESNY EADELSEEMA HLEGLMKDLN
AITTA
//
