ID   W5NCX1_LEPOC            Unreviewed;       622 AA.
AC   W5NCX1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0000313|Ensembl:ENSLOCP00000018480.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018480.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000018480.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   EMBL; AHAT01006201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NCX1; -.
DR   STRING; 7918.ENSLOCP00000018480; -.
DR   Ensembl; ENSLOCT00000018512.1; ENSLOCP00000018480.1; ENSLOCG00000015008.1.
DR   eggNOG; KOG1386; Eukaryota.
DR   GeneTree; ENSGT01100000263540; -.
DR   HOGENOM; CLU_010246_6_0_1; -.
DR   InParanoid; W5NCX1; -.
DR   OMA; WHDALFD; -.
DR   Proteomes; UP000018468; Linkage group LG1.
DR   Bgee; ENSLOCG00000015008; Expressed in testis and 13 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006256; P:UDP catabolic process; IBA:GO_Central.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        563..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        222
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         274..278
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   622 AA;  71069 MW;  6AEB0CF738BFB523 CRC64;
     FSRISFSCLF PASWHFSLSP VGLPRLPCLS LRQFLFLVLL VGTLCVLYLL LVLGKGKHSW
     LHRDKQFHRY LARVTDVEAT DTGNPNLNYG IVVDCGSSGS RVFVYCWPRH NGNPHDLLDI
     RQMRDQNRKP VVMKIKPGIS ELATAPEKAS DYIYPLLSFA AQHIPKSKHQ ETPLYILCTA
     GMRVLPESQQ EALLEDLRTD IPVHFNFLFS DSHVEVISGK QEGVYAWIGI NFVLGRFDHI
     EDEEEALVEV QVPGSDHQEA LVRKRTAGVL DMGGVSTQIA YEVPQTVSFA SSQQEEVAKN
     LLAEFNLGCD AHRTEHVYRV YVSTFLGFGG NAARQRYEES IVSKTLMENR LLGRHVGESS
     ETPFLDPCLP LDLEDKIEHG GQSLFLRGTG DFDRCQLVLQ PFMNKTNETQ TSLNGVYQPP
     IDYQNSQFYG FSEFYYCTED VLRMGGDYNA TKYSRAAKSY CTTKWKTLRE RFDRGLYASH
     ADLHRLKYQC FKSAWMYAVF HLGFSFPTEY RNMKTALLVY DKEVQWTLGA ILYRTRFLPL
     RDIQQEILKG AHSHWRGSFT FVINHYLFLA CFLVVLLSIL LYLLRLRRIH RRMLRNGLSS
     SSSSSTLWLE EGRGASAIPV TL
//