ID W5NEM2_LEPOC Unreviewed; 394 AA.
AC W5NEM2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=F-box protein 5 {ECO:0000313|Ensembl:ENSLOCP00000019081.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019081.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019081.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AHAT01027914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006638527.1; XM_006638464.2.
DR AlphaFoldDB; W5NEM2; -.
DR STRING; 7918.ENSLOCP00000019081; -.
DR Ensembl; ENSLOCT00000019113.1; ENSLOCP00000019081.1; ENSLOCG00000015506.1.
DR GeneID; 102696210; -.
DR KEGG; loc:102696210; -.
DR CTD; 26271; -.
DR eggNOG; ENOG502QPWN; Eukaryota.
DR GeneTree; ENSGT00530000063692; -.
DR InParanoid; W5NEM2; -.
DR OMA; WRRVICE; -.
DR OrthoDB; 3089336at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000018468; Linkage group LG16.
DR Bgee; ENSLOCG00000015506; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045835; P:negative regulation of meiotic nuclear division; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007088; P:regulation of mitotic nuclear division; IBA:GO_Central.
DR CDD; cd20364; BRcat_RBR_FBXO5; 1.
DR CDD; cd22170; F-box_FBXO5; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR047147; FBX5_43.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044064; ZF_ZBR.
DR PANTHER; PTHR15493:SF8; F-BOX ONLY PROTEIN 5; 1.
DR PANTHER; PTHR15493; F-BOX ONLY PROTEIN 5 AND 43; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00647; IBR; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51872; ZF_ZBR; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01220}.
FT DOMAIN 321..369
FT /note="ZBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51872"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 44173 MW; 27540EE2E5E2D8CF CRC64;
MKCPFAPLQK PSPVRSAEKD DGRHGTADFC REKRPLKEEP PVCFDPQRPG GPGASPVLLR
EPLRGVHNKE NRRTSLAVEL SDSRDFDSDC ILSGNVSQED SGYLSLHSSQ TEQGELGLGA
ADDDQKVPRR HHQHTRCSPS VTASPCGASP VALGLPVLHF QQTVCKELRR RYRRTQKFDW
GVVGEVAEDF RLQGVVGRKM GVEQLDIFEE LLERDMRHVL AKILRFLTDV DLINCQKVSK
TWRRVICEDK WAFQMCKTDK KDAETSGDFT TRDFAFSREV LSCLQVAAST PVHKPPRRKE
CGPSRHTEFQ QAADALKQHE ALKPCSHCGS PAKFDSYLRR ATCTRASCGF DFCTSCLCAY
HGSQSCRTGK RGQAREKTTL LPGSSRSKKN LKRL
//
