ID W5NF40_LEPOC Unreviewed; 655 AA.
AC W5NF40;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Solute carrier family 23 member 2 {ECO:0000313|Ensembl:ENSLOCP00000019249.1};
GN Name=SLC23A2 {ECO:0000313|Ensembl:ENSLOCP00000019249.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019249.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; AHAT01031450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01031451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01031452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01031453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NF40; -.
DR Ensembl; ENSLOCT00000019281.1; ENSLOCP00000019249.1; ENSLOCG00000015630.1.
DR GeneTree; ENSGT00950000182953; -.
DR OMA; NVSAYCR; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000015630; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR PANTHER; PTHR11119:SF33; SOLUTE CARRIER FAMILY 23 MEMBER 2; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 101..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 70678 MW; 3D831B46753D05F4 CRC64;
MGVGKNTTSK SMDSGGGADA KYEEEPSKHA TALIQVSLVV VNGAAQSAGD QDTEDTELMA
IYTREGGTAE KSSLSETLDS RDSMEAQRMD MIYTIEDTPP WYLCLFLGLQ HYLTCFSGTI
AVPFLLADAM CVGFDQWATS QLIGTIFFCV GITTLLQTTL GCRLPLFQAS AFAFLAPARA
ILSLEKWKCN TTEVPVLNST ELLHTEHIWH PRIREIQGAI IVSSLVEVCI GLLGLPGVLL
QFIGPLTITP TVALIGLSGF QAAGERAGKH WGIAMLTIFL VLLFSQYARN VQLPFPVYKS
KKGWTAYRLQ LFKMFPIIMA ILVSWLLCFI FTVTDVFPPE KDQYGFYART DARQGILSVA
PWFKIPYPFQ WGYPTVSAAG VIGMFSAVVA SIIESIGDYY ACARLSCAPP PPIHAINRGI
FIEGVSCVLD GLFGTGNGST SSSPNIGVLG ITKVGSRRVI QYGAALMLLL GLVGKFSALF
ASLPDPVLGA LFCTLFGMIT AVGLSNLQFI DLNSSRNLFV LGFSIFFGLV LPSYLKQNPL
VTGIVEIDQV LNVLLTTAMF VGGSVAFILD NTIPGSPEER GIRRLKRGAG KSTAELEGMR
SYDLPFGMDF LRRHRFFQYL PISPTFAGYG GRPCASVGRC GARAGEGGGA GESGV
//
