ID W5NFP5_LEPOC Unreviewed; 810 AA.
AC W5NFP5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Sortilin-like {ECO:0000313|Ensembl:ENSLOCP00000019454.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019454.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019454.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01016245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006633438.1; XM_006633375.2.
DR AlphaFoldDB; W5NFP5; -.
DR Ensembl; ENSLOCT00000019486.1; ENSLOCP00000019454.1; ENSLOCG00000015801.1.
DR GeneID; 102687967; -.
DR KEGG; loc:102687967; -.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_013596_0_0_1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015801; Expressed in pharyngeal gill and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106:SF46; SORTILIN ISOFORM X1; 1.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 739..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..728
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 810 AA; 90331 MW; B24EF9A2AEE446C0 CRC64;
MDPHVLVVSS LTRTKASNSK EPCVSAEFSG FAPHSCRTQT FSRTRTNREI SPRFKRDVSS
EGFTPCFSSL EAADLKKLKQ NTHETKFLDD DGSSFILSWV GDGTGVILVL STYNIPIDWF
FEQGSSHLYR SEDSGKTFSD ISHVINNTYI RKEFGINVGP GHSQRVILTA DTSGDGEKRG
VIFTSGDSGI SFQETTLPFH PGQVISYHPS NPDYLLVTST DKTLWLSVDF GQNWRKVHAN
VHSFSWGAGI TLFFSTSPKG TVDADRRGEL FLKRTEDLGK TFTTVSKNIF SFGYIGSFLF
TSVVEKPGKP RVIYVSSNQG DSFNQAQLPS ATLEQFYSVL EADAEMIFMH VDEPGDTNFG
TVYTSDDSGI VFSKSLERHL FSPEGKSDFT NITSLRGVYL TNVLEKDGRI RSVISYDRGG
EWRLLNKPEN VKCEASVKEC KLHIHGEYSR IQDLAPLIPL SDPSATGLVI AHGSVGDSIK
SARPDIYISD DGGYSWMRTL KGPHHYAILD SGGLIVAVEF NIDKAIKSIK FSTDEGQCWK
SYDFTQQPVT FAGLASEPGT KTMNISVWGY RTEEDSKVTW VSVTIDFEEL LTRDCEDKDY
VLWLAHSSNE ESSDNDGCVL GYKERFRRLK KLSVCRNGRD YIVSKEETPC PCTRHDYLCD
YGYYRHENSS ECIEQPAFEN HTLELCLNGQ EELLQTSGYR KVPGDKCEGG FTPQRKEKNI
NKQCGAFSQA SESKPETTIV TALTITIMIV ALSAAVFLIV RKYVFGGRIL AYRFSALQQQ
DDDPCITGNL NNVVSNGRGF HDDSDEDLIG
//
