ID W5NHN0_LEPOC Unreviewed; 948 AA.
AC W5NHN0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020139.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; AHAT01015721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015204072.1; XM_015348586.1.
DR AlphaFoldDB; W5NHN0; -.
DR STRING; 7918.ENSLOCP00000020139; -.
DR Ensembl; ENSLOCT00000020172.1; ENSLOCP00000020139.1; ENSLOCG00000016317.1.
DR GeneID; 102694135; -.
DR CTD; 553189; -.
DR eggNOG; ENOG502QR6U; Eukaryota.
DR GeneTree; ENSGT00940000155459; -.
DR InParanoid; W5NHN0; -.
DR OMA; PRCFCVE; -.
DR OrthoDB; 2904336at2759; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000016317; Expressed in larva and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032776; P:DNA methylation on cytosine; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd11729; ADDz_Dnmt3a; 1.
DR CDD; cd20154; PWWP_DNMT3A; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.720.50; PWWP, helical domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025766; ADD.
DR InterPro; IPR044108; ADD_DNMT3A.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR040552; DNMT3_ADD_GATA1-like.
DR InterPro; IPR049554; DNMT3_ADD_PHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23068:SF10; DNA (CYTOSINE-5)-METHYLTRANSFERASE 3A; 1.
DR PANTHER; PTHR23068; DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED; 1.
DR Pfam; PF17980; ADD_DNMT3; 1.
DR Pfam; PF21255; ADDz_Dnmt3b; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51533; ADD; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 328..386
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 518..650
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51533"
FT REGION 1..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 948 AA; 107438 MW; B3639A9F9482E3C9 CRC64;
MPSNATATTT TFKSSDFDYD AAANKMSEDQ EQDRGKEPGN SVPLRKVGRP GRKRKQLPVN
SCETSKEDVG SKCHASVESQ SSEQVHNGDV DSHPGDTIAA SSKQGRNIPE NGVPRESVRR
SEELPDQEAQ GQGYRKGRPD SSLENGFSTP PDDQDSEKDG EQVPPTPRKK RGRRKLEHPE
KHTEEQDESS CETVKTEQGT RARLRGGLGW ETSLRQRPMQ RITFQAGDPY YISKRKRDEW
LAKWKMEAEK RAKLVAVMNA MEEPAGNEAQ KEEEEVVVNQ LPPQQHTDPA SPTVATTPEP
VSAETVDKSI PKSTDVEPEY EDGRGFGIGE LVWGKLRGFS WWPGRIVSWW MTGRSRAAEG
TRWVMWFGDG KFSVVCVEKL MPLSSFSNAF HQPTYNKQPM YKKAIYEVLQ VASSRAGKIF
PTCPDTDETD TSKSVDLQNK QMIEWAMGGF QPTGPKGLEP PEEERNPYKE VYTEMWVEPE
AAAYTPPPPA KKPRKSTAEK PKIKEIIDER TRERLVYEVR QKCRNIEDIC ISCGSLNVSL
EHPLFLGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR EVLMCGNNNC CRCFCVECVD
LLVGPGAAQA AIKEDPWNCY MCGTKGIYGL LKRREDWPSR LQHFFANNHD QDFDPPKLYP
PVSAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVERYIASE VCEDSITVGI VRHQGRIMYV
GDVRNVTRKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY EGTGRLFFEF YRLLHEARPK
EGDDRPFFWL FENVVAMGVS DKRDISRFLE CNPVMIDAKE VSAAHRARYF WGNLPGMNRP
LAAMTNDKLD LQDCLEHGRT AKFSKVRTIT TRSNSIKQGK DQHFPVYMNE KEDILWCTEM
ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP LKEYFACL
//
