ID W5NKS7_LEPOC Unreviewed; 1247 AA.
AC W5NKS7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSLOCP00000021236.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000021236.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000021236.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AHAT01037767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01037768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01037769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01037770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01037771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01037772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015208857.1; XM_015353371.1.
DR AlphaFoldDB; W5NKS7; -.
DR STRING; 7918.ENSLOCP00000021236; -.
DR Ensembl; ENSLOCT00000021272.1; ENSLOCP00000021236.1; ENSLOCG00000017174.1.
DR GeneID; 102698288; -.
DR KEGG; loc:102698288; -.
DR CTD; 100004946; -.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000158693; -.
DR HOGENOM; CLU_001390_0_1_1; -.
DR InParanoid; W5NKS7; -.
DR OMA; LAVCCRM; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000017174; Expressed in pharyngeal gill and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 824..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..379
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 838..1089
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 141192 MW; 9B32F60EE96DC90B CRC64;
MRIADKEKDG AGAGAGAGAG AGAGGQAGAK NGSTNQNWIP KIFQKRACTN FIEDTSSNGA
LCQCGGTRQS HASVATEDHF GAAIVSKWDS AQHTTELPTD AFGDVEFAGK SKRLSHFLRL
SCNTDPQSVY RLMTSHWAIP VPNLVVSVCG GGGKLKMKSW VREVLRQGLV KAAQGTGAWI
LTGGLCEGIG RYVGEAVRDH ATASTQSNTK VIAVGIASWG IVHNREQLVN PQGSFPARYY
VQNTSCDTFC LDNNYQAFLL VDDGSVGRSG GETGFRARLE NYISHQRTGI WGSGNIEIPV
LCMLVAGDEA MLERVDRSLQ DSTPWLVLAG TGGMADFLCE VLQEFSSIEQ DELAEFLQEL
LKKHFPHSTE KLALLTERVI RIMQSRELLN VYDAEQDGSE DFDTVILKAL VRACKRQSSD
SSEYIEELKL AVAWNRVDIA KSELFNGDVV WKYADLEDSM TDALVNNKPE FVRLFTENGL
NILDYLTYGR LEQLYCALPV NSLAHQLLDR RRHERRGSSL HSLDTPAAPG PAPAEPAAAP
ARELTLFEVS RVLRDLLGDA CEPFYSKCLG LSRSSGSRKS LKRMNKLLLG DCSYRQDRCA
SPWIDLFIWA VLQDRSKMAT FFWEMAGDSV TSALAASKML RELSRLQYDT ESKLSMKDLA
NRFENLAHDV FSECYKNDEM RCFLLLIRRS PFWGKATCLQ LATVADARLF FSHDGVQALL
TRIWWGDMDS STEVWKLIAT FFCPPLVYTS LIKYREVEEE VKNEEPQAKE LDSCDGDTIF
SMKDITKNPE EMEELESLKE KPRDRPAHSP GKPRPYVVAR WRQFWFAPVT SFLGNVLMYF
LFLLLFASVL LVDFKQPPPD GPSPKELFLY FWVFTLVCEE IRQTFFIGNL SVLKRMKVYI
QDMWNKCDLT AIVLFIIGLC CRMFLPTFEF GRAVLCLDFM VFALRLLHIF AVNKQLGPKI
IIVGKMMKDI FFFLFFLGVW LMAYGVANQA LLYPYEPRAE WIMRRVFYRP YLHIFGQIPL
EDIDAAKMSG EGNCSYDAEE IHMGMEPCTN TYANWLVIIL LVVYLLVTNI LLLNLLIAMF
SYTFSKVQGN SDIYWKFQRY NLIVEYHNRP ALAPPFILLS HINLLIKRNI RKVPSVKIQH
FMLDLSKQKD NRLLTWEAIQ KENFLAQQNK CKRESDSERL KRTSNKVDNV LKHMAEIRDH
DRRLKVLESE MEYCSSALSW MVEALSQSNV IKATRPPPTH KDPTTPL
//
