ID W5NMM2_LEPOC Unreviewed; 828 AA.
AC W5NMM2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=SLIT and NTRK like family member 6 {ECO:0000313|Ensembl:ENSLOCP00000021881.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000021881.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000021881.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01022690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015219107.1; XM_015363621.1.
DR RefSeq; XP_015219108.1; XM_015363622.1.
DR AlphaFoldDB; W5NMM2; -.
DR STRING; 7918.ENSLOCP00000021881; -.
DR Ensembl; ENSLOCT00000021919.1; ENSLOCP00000021881.1; ENSLOCG00000017777.1.
DR GeneID; 102697383; -.
DR KEGG; loc:102697383; -.
DR CTD; 84189; -.
DR eggNOG; ENOG502QZTX; Eukaryota.
DR GeneTree; ENSGT00940000160718; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; W5NMM2; -.
DR OMA; RNPTYCS; -.
DR OrthoDB; 3974211at2759; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000017777; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IBA:GO_Central.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR45773:SF1; SLIT AND NTRK-LIKE PROTEIN 6; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..828
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867836"
FT TRANSMEM 592..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..268
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 502..552
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 828 AA; 94426 MW; 078445BC952EA272 CRC64;
MFTWIILICL SIAVANFQNI QPNKAFSKGF CDALCTCEEK DGVLYINCEE RNISKVTQVK
VPPDTPFHLT LYKNDIVELH PDEMEHLKNA VSLHLGTNSI QELEPGVFSA LGSLKKLHIN
SNFIVILKED TFHGLVNLEY LQADTNFISV IEYGAFSKLI RLKVLILNDN SLEFFPSNIF
RFLPLTHLDL RGNHLKTLPY VGFLEHIGGI MELLVEDNEW FCDCEILPLK IWIENMRFKS
AIGEVVCNSP MQLKGSILSR VKREILCPSH AEIDLEKLSK TSTMAITPSS KVIPIKNLTQ
GDGTTPALVP GVACLKQCPC HKHPTIGLLI HCQDKGIQRI SDLGLPHESP RELVLTGNMI
QNLLQYDFVE YGSLKFLNLA NNQIENIDDE TFLSLRHLKR LYLNGNKLTR LSPGMFAGLY
NIEYLYLEYN MIKEILSGTF STMPNLKLLS LNNNRLQTLP PLIFHSMPLA ELDLRKNLFM
HLPVSNVLDH LDSLERIYLE DNPWDCSCDL VGLKQWIEKL NKDTIVGTML CHSPRKVAKT
DLRFLRNELL CPGLVTFYSL PTHDNNGGVT TSATTTSTAG NLFMSFTDAV PLSVLILGLL
IVFLMIVFCA AGLVVLVLHR RRRSKKKQTD DQPRENSPIH LHYSMFGQRT THHMSQRPGA
TVCNEPTHNP IGQVCRSPTY NVHLKEQEQD EFDLNDSKNV CRRILEKEND SPMTGLNRKF
RAVTEYPPEF VTLGDADSLY RNILEREREL QQLSITEYLR KNISQLQPAV EVHGHGRHEE
LKLMETIMYT RPRKVTVEQT KNEYFELKAN LHTEPDYLEV LEQQTTLN
//
