ID W5NQD6_SHEEP Unreviewed; 955 AA.
AC W5NQD6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Seizure related 6 homolog like {ECO:0008006|Google:ProtNLM};
GN Name=SEZ6L {ECO:0000313|Ensembl:ENSOARP00000000376.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000376.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000376.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000376.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000376.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AMGL01039702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01039703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01039704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NQD6; -.
DR SMR; W5NQD6; -.
DR STRING; 9940.ENSOARP00000000376; -.
DR PaxDb; 9940-ENSOARP00000000376; -.
DR Ensembl; ENSOART00000000404.1; ENSOARP00000000376.1; ENSOARG00000000375.1.
DR eggNOG; ENOG502QVYR; Eukaryota.
DR HOGENOM; CLU_011474_1_0_1; -.
DR OMA; NRDCFGN; -.
DR Proteomes; UP000002356; Chromosome 17.
DR Bgee; ENSOARG00000000375; Expressed in cerebellum and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF8; SEIZURE 6-LIKE PROTEIN; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 888..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 211..319
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 321..380
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 382..492
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 495..556
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 558..669
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 673..732
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 734..797
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 802..863
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 1..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 211..238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 382..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 703..730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 955 AA; 104325 MW; CABB6F482DFDC7F3 CRC64;
DEPPEGDAGQ SDTYLLPSEI LGSSSLSKEN PEESVTTAPL NPVQSGDELR EPELEGTVPF
APQDPAAVST LLPLPEEPGT RHAFPARKKP PSLKQVNLAR KQLRPKATLA AATQRTASPG
PGLLAAAPGK PRPPGGQPGR PPPPRDPPTG GAAAVPEEAP EAPLEDASPE TLTDKGETEL
TGSASEESQE TTTSTIITTT VITTEQAPAV CSVSFSDPEG YIDSSDYPPL PLHNFLECTY
NATVYTGYGV ELQVKSVNLS EGELLSIRGV DGPSLTVLAN HTLLVEGQVI RSPTNTISVY
FRTFQDDGLG TFQLHYQAFM LSCSFPRRPD FGDVTVMDLH SGGEAHFHCH LGYELQGAKT
LTCINASKPH WSSREPICSA PCGGAVHNAT IGRVLSPSHS ANASGSQFCV WTIEAPEGQK
LHLHFERLAL HEKDRMMVYS GLTNKSTLLY DSFQTENVPF EGLLSDGHTI RIEFTSHQPP
AASAFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTVV EFTCDPGHSL EQGPAIIECI
NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV GEEKRIFLDI
QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD PAGLIFGKGQ
GFIMNYIEVS RNDSCPDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV GSDTLTCQWD
LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL EGSSLLTCYS
RETGSPIWTS RLPHCAVPEE SLACDNPGLP ENGYQILYKR LYLPGESLTF MCYEGFELMG
EVTIRCILGQ PSHWSGPLPV CKVNQDSFEH ALEVAEAAAE TSLEGGNMAL AIFIPVLIIS
LLLGGAYIYI TRCRYYSNLR LPLMYSHPYS QITVETEFDN PIYETGETRE YEVSI
//
