ID W5NQS4_SHEEP Unreviewed; 376 AA.
AC W5NQS4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN Name=HSH2D {ECO:0000313|Ensembl:ENSOARP00000000514.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000514.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000514.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000514.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000514.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01090945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012033121.1; XM_012177731.2.
DR AlphaFoldDB; W5NQS4; -.
DR SMR; W5NQS4; -.
DR STRING; 9940.ENSOARP00000000514; -.
DR PaxDb; 9940-ENSOARP00000000514; -.
DR Ensembl; ENSOART00000000542.1; ENSOARP00000000514.1; ENSOARG00000000506.1.
DR GeneID; 101117244; -.
DR KEGG; oas:101117244; -.
DR CTD; 84941; -.
DR eggNOG; ENOG502RZYN; Eukaryota.
DR HOGENOM; CLU_067582_0_0_1; -.
DR OMA; CGQKDPA; -.
DR OrthoDB; 5360547at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000000506; Expressed in gastric lymph node and 51 other cell types or tissues.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14388:SF3; HEMATOPOIETIC SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14388; T CELL-SPECIFIC ADAPTER PROTEIN TSAD; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 68..159
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41775 MW; 6A8758453FEB6115 CRC64;
MGSRLDQKES QSWRGPERQD EPSGGTGQPS SLEAMTEARR LPPPLPPRLD WFVQTQVDQL
TCEGVPEWFH GAISREDAEN LLESQPPGSF LIRVSHSHVG YTLSYKAQNC CHHFMVKLLD
DGSFMITGEE RVHDSLDALV TFYQQKPLWP HGDLLMQPCP QKDPVNVDYE DLFLYSNALA
EEASSSALGF SEHQIPSSYP MAPLKEGSAK PGLLHRSKER KLSPRLEGAS MEGPLEEACQ
KLWRNLRMLP KTGRKVQKQL KSHLGALSSS SVTGGSETGT GDTAWENNVD KDPFVATSLA
SPPQPQAPRS RQSPSRKTSR SVSWSEATSK VRDWHQTVVR FLSIQASKPG PADLREPQDS
LPEEYHPPPP FAPGYC
//
