ID   W5NRB1_SHEEP            Unreviewed;      1002 AA.
AC   W5NRB1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Multimerin-2 {ECO:0008006|Google:ProtNLM};
GN   Name=MMRN2 {ECO:0000313|Ensembl:ENSOARP00000000701.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000701.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000000701.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000701.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000000701.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AMGL01071930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NRB1; -.
DR   STRING; 9940.ENSOARP00000000701; -.
DR   PaxDb; 9940-ENSOARP00000000701; -.
DR   Ensembl; ENSOART00000000733.1; ENSOARP00000000701.1; ENSOARG00000000684.1.
DR   eggNOG; ENOG502QUTH; Eukaryota.
DR   OMA; NHMSTSV; -.
DR   Proteomes; UP000002356; Chromosome 25.
DR   Bgee; ENSOARG00000000684; Expressed in mitral valve and 51 other cell types or tissues.
DR   ExpressionAtlas; W5NRB1; baseline.
DR   GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   PANTHER; PTHR15427:SF6; MULTIMERIN-2; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..1002
FT                   /note="Multimerin-2"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004869711"
FT   DOMAIN          59..137
FT                   /note="EMI"
FT                   /evidence="ECO:0000259|PROSITE:PS51041"
FT   DOMAIN          829..970
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
FT   REGION          26..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          169..196
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          400..483
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1002 AA;  110145 MW;  253C1F77FEBBB185 CRC64;
     MILTLLFGLG GPLGWGMLGT WAQAPGASFS DPHSPQPPGP EQGGGWRAEA EDSGGDPVRR
     NWCPYQRSRL VTFVAACKTE KFLVHSQQPC PQGAPNCQKV KVMYRVAHKP VYQVKQKVLA
     SVAWRCCPGF AGPDCQHHDP TAIPEPEDPG DGLQEAWDGP VDFESGHPAA EIRNTVERQE
     RRLGDLQNDI HQMADSLPGL WEAWASNLTV ATTEANQTEL EFPGRSLEQA LLPHINTFLQ
     GHLSPMWRSF NQSLHSLSQV IRNLSLDVEA NRQALKRVQE TSVARADFQE LGTKFETKVQ
     ENAQRVGQLR QDVEDRLHAQ RLSLHQSLSE VQTDMDIKLK KLLKAQESVG INSSLVFAAA
     GAAARPEPES LNARLGQLQR NLSALHVATA HREEALQSTL ADMKATLARH VDEIKELYSE
     SDDTFDEISK VQRQVQELEV NHTALRELRV ILMEKSLVME ENKEDVERQL LELNLTLQHL
     QGAHADLIKY VKDCNCQKLY FDLDVIREDQ RDTTRALEET QVSLDERRQQ DGSSLQALSD
     TVASLSLAVN TQQAEGERAQ AEAARLRSQL RALGGEVSAL RAAETEIRRE IRQLHSSFSA
     LLEDALRHEA VLAALFGEEV MEEMSEEGPG TLPLRYEQAP ALRTEPRHPD GRGQRAAGAG
     FRLGCTGRQG DCLGTVLGGP PANRAFGAQP GPPPEVEPSR DAPPEEVGGL DLAGLAQELQ
     RLSSDMEGMG RCCEASWVSS LNSSLEGLRG ELSTTERVLE RHQHLFHSLF GNFQGLVAAN
     VSLDLEKLQA MLNRKGKKQQ KGLEAPKRRD RKQVESLGDV RVKGPALWEA GYPVAFYASF
     SEGTTALQIV KFNTAYINVG SSYFPEHGYF RAPERGVYLF AVSIEFGPGP GTGQLVFGGH
     HRTPVYTTEE QRGGSPATTF AMAELQKAQA RLSTPLPCLL ARASCLLPLS RKSNPDSRYD
     TFPPLLATDG KASTRPPLLL EAQAVSSLLS PAVTGQAVLT TK
//