ID W5NRD7_SHEEP Unreviewed; 382 AA.
AC W5NRD7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN Name=PAG5 {ECO:0000313|Ensembl:ENSOARP00000000727.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000727.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000727.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000727.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000727.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AMGL01061551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NRD7; -.
DR SMR; W5NRD7; -.
DR STRING; 9940.ENSOARP00000000727; -.
DR PaxDb; 9940-ENSOARP00000000727; -.
DR Ensembl; ENSOART00000000759.1; ENSOARP00000000727.1; ENSOARG00000000700.1.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_0_1; -.
DR OMA; CIVEIPL; -.
DR Proteomes; UP000002356; Chromosome 21.
DR Bgee; ENSOARG00000000700; Expressed in gastric lymph node and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..382
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867967"
FT DOMAIN 72..379
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 90
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 271
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 103..108
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 262..266
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 304..338
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 382 AA; 42298 MW; B4ABC7CD2B1B9CEC CRC64;
NMKWLVLLGL VALSECIVEI PLMKVNVMQE TLNEKSLLNN FLKKYAYRLA QNSTRNSKMA
FVPMRNFLDT AYVGNIAIGT PPQQFRVVFD TGSSDLWVPS NFCTSPACYS HITFKYWESS
TYRHTTKPFE IAYGSGRIKG HLAYDTIQIG NLVSTDQPFG LSLEEYGFNG LPFDGILGLN
YPNNSILGAI PIFDNLKKQG AISEPIFAFY LSKGTVNGSV LMLGGVDKAY YKGQLNWIPL
SRVGDWRINL DHISMKGKLI GCSGGCEALV DTGTSLINGP TRLVTNIQRL IGAMPLGPKH
YVSCSTINIL PSIIFTINGI NYTLPAQAYI LKNSQGGCFS TFKGGTEVFK HRETWVLGDI
FLRLYFSVYD RGNNRIGLAQ AA
//
