ID   W5NRG7_SHEEP            Unreviewed;       917 AA.
AC   W5NRG7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H4 {ECO:0008006|Google:ProtNLM};
GN   Name=ITIH4 {ECO:0000313|Ensembl:ENSOARP00000000757.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000757.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000000757.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000757.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000000757.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   EMBL; AMGL01045508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NRG7; -.
DR   SMR; W5NRG7; -.
DR   STRING; 9940.ENSOARP00000000757; -.
DR   PaxDb; 9940-ENSOARP00000000757; -.
DR   Ensembl; ENSOART00000000789.1; ENSOARP00000000757.1; ENSOARG00000000729.1.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   HOGENOM; CLU_008101_0_0_1; -.
DR   OMA; EFIYWIN; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   Bgee; ENSOARG00000000729; Expressed in mitral valve and 50 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..917
FT                   /note="Inter-alpha-trypsin inhibitor heavy chain H4"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004868098"
FT   DOMAIN          20..149
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          275..458
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          596..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..619
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   917 AA;  101815 MW;  D12EF7A16EDFD320 CRC64;
     METPAPGRTH RVVLVLLSLA VLHTSKAQKV QNDIDIYSLT VDSKVSSRFA HTVITSRVVN
     KADAVREATF QMELPKKAFI TNFSMVIDGV TYPGNIKEKA AAQEQYSAAM ARGESAGLVT
     ATGRKTEQFQ VSVSVAPAAK VTFELVYEEL LARHLGVYEL LLKVRPQQLV KHLQMDIHIF
     EPQGISFLET ESTFMTNELA EALTTSQNKT KAHVRFKPTL SQQQKSPEKQ DTVLDGNFIV
     RYDVDRPVSG GSIQIENGYF VHYFAPDSLS TMPKNVIFVI DKSGSMMGRK IKQTQEALIK
     ILDDLSPHDQ FNLISFSAEA TKWKPLLVPA STENVNEAKS YATGIRAQGG TNINDAMLMA
     VQLLEKANRE ELLPAGSITL IILLTDGDPT AGETDPLKIQ ENVRKAVNGQ HSLFCLGFGF
     DVSYAFLEKM ALENGGLARR IYEDSDSALQ LQDFYQEVAN PLMMSVAFEY PSNAVESVTQ
     DAFRVFFKGS ELVVAGKLRD HSPDVLSAQV RGQLHRENIT FVMESHVAEQ EEMFRGPKYI
     FHSFMERLWA YLTIQQLLEQ MVSALDAEKQ ALEARALNLS LSYSFVTPLT SMVITKPEGQ
     EQSQVAEKPV EDENRDRRVP LAGPMGFGQS MDRASWKTGG GLKLLNSPPR LGVPGRFLAP
     PPPFYRTTSR LVLPELTLQL TPAPTPSPTS GPGGASYDMD FRIKGTTVTA PPLAPVQAPS
     VILPLPGQSV DQLCVDFRRP QELVNLLSDP DQGVEVTGHY ETAKACFSWI EVTFQNPQLQ
     VHASPEHVVI TRNRRNSAYK WKETLYSVMP GLKVTMDKAG LLLLSRPDRV TIGLLFWDGP
     GKGLRLLLQD TDRFSSHVSG TLGQFYQDVL WGPLDTADDR KRTLKVQGRD YSATRELKLD
     YQESPPGKEI SCWSVEL
//