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Database: UniProt
Entry: W5NTS9_SHEEP
LinkDB: W5NTS9_SHEEP
Original site: W5NTS9_SHEEP 
ID   W5NTS9_SHEEP            Unreviewed;      1932 AA.
AC   W5NTS9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSOARP00000001573};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001573, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000001573, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001573};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000001573}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000001573}.
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DR   EMBL; AMGL01044297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01044298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000001616; ENSOARP00000001573; ENSOARG00000001512.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    722    740       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    773       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    785    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    842    865       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    885    902       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    922    945       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1251   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1300       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1444   1470       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1616       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1749   1772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    425       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      481    653       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      722    949       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      959   1206       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1210   1479       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1528   1637       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      416    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1932 AA;  217341 MW;  8FCA4925CE62616F CRC64;
     MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESRDGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
     RRAAVKILVH SSFNMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTVLNGT NSTNGSVEAD
     GLIWGSLDLY LNDPENYLLK NGTSDVLLCG NSSDAGTCPE GYRCLKAGEN PDHGYTSFDS
     FAWAFLALFR LMTQDCWERL YQQTLRSAGK IYMIFFMLVI FLGSFYLVNL ILAVVAMAYE
     EQNQATIAET EEKEKRFQEA MELLKKEQEA LAIRGVDTMS RSSLEMSPLA PVTTHERRSK
     RRKRMSSGTE ECGDDKFPKS DSEDGPRAVN RFSITHGLSR TSMKPRSSHG SIFTFRRRDL
     GSETDFADDE NSTAGDSESH RTSLLVPWPL RRPSTQGQSP GWGRAPPGPP PQGATSSTVD
     CNGVVSLLGA GDPEAASPGS HLLHPMKLER PPDTTTPSEE PGRPQTLTPQ GPSLARFPSP
     CHVAALSSAG CVIQLFWKEL EESQRRCPPC WVRLAQRYLI WECSPLWMSI KQTVKFMVMD
     PFADLTITMC IVLNTLFMAL EHYNMTAEFE EMLQVGNLVF TGIFTAEMTF KIIALDPYYY
     FQQGWNIFDS IIVILSLMEL GLSRMGNLSV LRSFRLLRVF KLAKSWPTLN TLIKIIGNSV
     GALGNLTLVL AIIVFIFAVV GMQLFGKNYS ELRHRISDSG LLPRWHMMDF FHAFLIIFRI
     LCGEWIETMW DCMEVSGQSL CLLVFLLVMV IGNLVVLNLF LALLLSSFSA DNLTAPDEDG
     EMNNLQLALA RIQRGLRFIK RTTWDFCCGL LQRPPQKPAA FASQGQLPGC IATSSPPPPP
     ESEKAPPARK ETRFEEGQRP GQGAPGDAEP VCVPIAVAES DTDDPEEDEE NSLSTEEGSS
     KQQESQPASV SPEALPEPRV WSQVSETTSS GAEASEAQAD LQRQRRAEAP APGCSELPED
     SYSEGSTADM TNTADLLEQI PDLGEDVKDP EDCFTEGCVR RCPCCTVDTT QAPGKVWWRL
     RKTCYRIVEH SWFETFVIFM ILLSSGALAF EDIYLEERKT IKVLLEYADK MFTYVFVLEM
     LLKWVAYGFK KYFTNAWCWL DFLIVDVSLI SLVANALGFA EMGPIKSLRT LRALRPLRAL
     SRFEGMRVVV NALVGAIPSI MNVLLVCLIF WLIFSIMGKF GRCINQTEGD LPLNYTIVNN
     KSDCESFNVT GELYWTKVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRGYEEQPQW
     ECNLYMYIYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKL GGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPLNKYQGF IFDVVTKQAF DVSIMFLICL NMVTMMVETD DQSPEKVNIL
     AKINLLFVGI FTAECIFKMV ALRHYYFTNS WNIFDFVVVI LSIVGGFHLS AMYSLFSGTE
     GKTGAKRGAA VARVMRRCLE AGSGLRKCSR RSQAGMRLRP CLLGLERIFS LKPTFVSGIR
     EVWKVHLGQY KASIFHSFFY NLRLCSLKLQ TQSSTVLSDI IQKYFFSPTL FRPTSNGSRG
     NCGSPAVGIL FFTTYIIISF LIVVNMYIAI ILENFSVATE ESTEPLSEDD FDMFYEIWEK
     FDPEATQFIE YSRKHEEVSA TVIQRASRRH LLRRSVKPAS FLYRQQAGSS GLSEEDAPEQ
     EGLIAYMMNE NFSRRLGPPS SSSVSSTSFP PSYDSVTRAT SDNPQVRASD YSPSEDLADF
     PPTPDRDRES VV
//
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