ID W5NU00_SHEEP Unreviewed; 1043 AA.
AC W5NU00;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001644.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000001644.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001644.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000001644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AMGL01059036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01059037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000001644; -.
DR PaxDb; 9940-ENSOARP00000001644; -.
DR Ensembl; ENSOART00000001687.1; ENSOARP00000001644.1; ENSOARG00000001568.1.
DR eggNOG; KOG1366; Eukaryota.
DR HOGENOM; CLU_001634_4_1_1; -.
DR OMA; NAVVIMD; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000001568; Expressed in aortic valve and 50 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 2.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR048847; C4_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21145; C4_MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1043
FT /note="Alpha-2-macroglobulin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868194"
FT DOMAIN 453..521
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1043 AA; 113817 MW; 54D5620DC8E9C829 CRC64;
MRLLWGLIWA SGFFALSLQK PRLLLFAPSV VRIGVPLSVA VKLQDAPSGQ VVRGSVFLRN
PSHVNELCSP KVDFSLSSGR DFILLNLPIP HEQARLCRLH LLRGAPEVQL MVQSPWLRDS
LSKQTDTQGV NLLFSSRRGH LFLQTDQPVY NPGQRVRYRV FALDQKMRPA SDILTVTVEN
SQGFRVQKRE VFTPSSIFQD NFLIPDISEP GTWKISARFS DSLDSNSSTQ FEVKKYVLPN
FEVKIIPENP YILTTPGFLS DIQVIIQARY IYGKPVQGVA YVRFGLLGED GEKTFLWGLE
SQTKLVDGQC QISLQKAEFQ GVLEKLNISI NDLPGLRLYV AAAVIESPGG EMEEAELTSW
RFVSSPFSLD LSKTKQQLIP GVPFLLQALV RDMSGSPASG IPVKVSAKLF SGSTSKNQDF
ERNTDGSGQV IVSLXWGGKL GSRGRPCPTL LESPWCDAPR PLICAHSVSG LCVATPARLR
VFREFHMHLR LPVSVRRFEQ LELRPVLYNY LDRDLTVSVR VSPVEGLCLA GGGGLAQQVQ
VPAGSARPVG FSVVPIAAAA VSLKVVARGS FDFPVGDAIS KILQVEREGA LHREEIVYDL
NPLDPRGRTL EIPGNSDPNI VPEGDFKSFV RVTASDPLEA LGSEGALSPG GLASLLRLPQ
GCGEQTMTLL APTLAASRYL DKTEQWSLLP PETKDRAVDL IQKGYTRIQE FRKRDGSYGA
WLHRDSSTWL TAFVLKILSL AQDQVGGSTK KLQETAMWLL SQQRDDGSFH DPCPVIHRDM
QGGLVGSDET VALTAFVVIA LHHGLAVFLD KNSEQLRRVE NSISRANTFL GAKATSGLLG
AHASAITAYA LSLTEAPEDL RNIAHNNLMA MAKNIGDKLY WGSVTTSPSN VLSPTLAPRS
PADPIPQAPA MSIETTAYGL LHLLLWEGKA ELADQAASWL TGQGSFQGGF RSTQDTVMAL
DALSAYWIAS HTTEETGVNV TLSSLGRSGL KSHVLQLTNH QVHRLEEELQ FSLGSKINVE
VRGNSRGTLK VRAGGTGRAG PSG
//
