ID W5NWM2_SHEEP Unreviewed; 370 AA.
AC W5NWM2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Apolipoprotein A-IV {ECO:0000256|ARBA:ARBA00041197};
DE AltName: Full=Apolipoprotein A4 {ECO:0000256|ARBA:ARBA00042591};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002569.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002569.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002569.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002569.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR EMBL; AMGL01031433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NWM2; -.
DR SMR; W5NWM2; -.
DR STRING; 9940.ENSOARP00000002569; -.
DR PaxDb; 9940-ENSOARP00000002569; -.
DR Ensembl; ENSOART00000002622.1; ENSOARP00000002569.1; ENSOARG00000002419.1.
DR eggNOG; ENOG502QSC5; Eukaryota.
DR HOGENOM; CLU_058447_0_0_1; -.
DR OMA; VIWKYFT; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000002419; Expressed in jejunum and 16 other cell types or tissues.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 1.20.5.20; -; 1.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF1; APOLIPOPROTEIN A-IV; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; HDL {ECO:0000256|ARBA:ARBA00022850};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..370
FT /note="Apolipoprotein A-IV"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868395"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..292
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 370 AA; 41480 MW; 3B57127174D08DE5 CRC64;
MFLKAVVLSL ALVAVTGAEA EVNADQVATV IWDYFSQLGN NAKKAVEHIQ KSELTQQLNL
TFQSVTNGHI LALRLPEERE GEKCHKMLEE VQREIQRYKV NVLQPHGGPL ASFPRSTLFQ
DKLGEGPYAE ELRSQVDTQA QQLRRQLTPY AQRMETVMRQ NLDQLQASLA PYAEELQATV
NQRVEELKGH LTPYADQLQT KIEENVEELR RSLAPYAQDV QGKLNHQLEG LAFQMKKHAE
ELKAKISAKA EELRQGLVPV VNSVRGSQPG NAEGLQKSLA ELSSRLDQQV EDFRRTVGPY
GETFNKAMVQ QLDALRQKLG PLAGDVEDHL SFLEKDLRDK VSSFFNTLKE KESQAPALPA
QEEIPVPLGG
//
