ID W5NWV8_SHEEP Unreviewed; 349 AA.
AC W5NWV8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein {ECO:0000259|Pfam:PF03807};
GN Name=NOXRED1 {ECO:0000313|Ensembl:ENSOARP00000002655.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002655.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002655.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002655.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002655.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
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DR EMBL; AMGL01104627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NWV8; -.
DR STRING; 9940.ENSOARP00000002655; -.
DR PaxDb; 9940-ENSOARP00000002655; -.
DR Ensembl; ENSOART00000002708.1; ENSOARP00000002655.1; ENSOARG00000002500.1.
DR eggNOG; KOG3124; Eukaryota.
DR HOGENOM; CLU_075978_0_0_1; -.
DR OMA; CIVYSFV; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000002500; Expressed in testis and 2 other cell types or tissues.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR PANTHER; PTHR11645:SF58; NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 79..166
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
SQ SEQUENCE 349 AA; 39477 MW; F6E3A0823A844045 CRC64;
MDLLEDLETL KFESGIHEED QSWLYLLGRS HGLMTKACAH ATFFCKQLHN LRKLVPEKRA
SKCRLTGLCE ETQDDDALKV GIIGGGHLGK QLAHTLLQFV PIPAENLRIS TRRPETLDEF
KKLGIQCFYQ NASLVGWANV VFLCCLPSQL PNICVEIQTR LGKDCIVYSF VSAIPVPRLK
LLLNHTNILR PQYQCAEDLA HIWGANKEIT AALQDPVIIQ ATCPYSPAGG ISLNIKWLEG
MFYALLNFCT AKDMPHSQVL QHLSELFLSQ HLEACKKDEA SPLKFQAQDF VSKIYAKNLS
QKRPFPLFDL TAVQLKETPF SQYLSNSTTF QDHFTHLYYD SFGISLTKE
//
