ID W5NX00_SHEEP Unreviewed; 431 AA.
AC W5NX00;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Gastricsin {ECO:0000256|ARBA:ARBA00023821};
DE EC=3.4.23.3 {ECO:0000256|ARBA:ARBA00023796};
GN Name=PGC {ECO:0000313|Ensembl:ENSOARP00000002697.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002697.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002697.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002697.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002697.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Hydrolyzes a variety of proteins.
CC {ECO:0000256|ARBA:ARBA00023749}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=More restricted specificity than pepsin A, but shows
CC preferential cleavage at Tyr-|-Xaa bonds. High activity on
CC hemoglobin.; EC=3.4.23.3; Evidence={ECO:0000256|ARBA:ARBA00023733};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AMGL01058619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01058620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01058621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004018860.1; XM_004018811.3.
DR AlphaFoldDB; W5NX00; -.
DR SMR; W5NX00; -.
DR STRING; 9940.ENSOARP00000002697; -.
DR MEROPS; A01.003; -.
DR PaxDb; 9940-ENSOARP00000002697; -.
DR Ensembl; ENSOART00000002750.1; ENSOARP00000002697.1; ENSOARG00000002540.1.
DR GeneID; 101106633; -.
DR KEGG; oas:101106633; -.
DR CTD; 5225; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_0_1; -.
DR OMA; GFWTIDI; -.
DR OrthoDB; 1120702at2759; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000002540; Expressed in abomasum and 9 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF72; GASTRICSIN; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..431
FT /note="Gastricsin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868138"
FT DOMAIN 74..388
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 92
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 278
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 105..110
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 312..346
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 431 AA; 47261 MW; D47EA96BC375A8BF CRC64;
MKWMVLALVC LQALAAAALV KIPLKKFKSI RETMKEKGLL EDFLRTYKHD PAQKYHFGDF
SVATEPMDYM DAAYFGEISI GTPPQNFLVL FDTGSSNLWV PSLYCQSQAC TSHPRFNPSL
SSTYSSNEQT FSLQYGSGSL TGLLGYDTLT VQGIQVPNQE FGLSKTEPGT NFLYAKFDGI
MGMAYPSLSV DGATTVLQGM VQEGALTSPI FSFYLSSQQG SQDGGAVIFG GVDSRLYTGQ
IYWAPVTQEL YWQIGIEEFL IGDQATGWCS AGCQAIVDTG TSLLTVPQQF LSALLQATGA
QKDQYGQFPV DCNNIQNLPT LTFVINGMQF PLPPASYILS NGDSYCVLGV EVTYIPSQNG
QPLWILGDVF LRSYYSVYDL GNNRVGFATA AKTQRLDSRA SFSFWTLHPT GASLYTSSLH
LASLLWTLDF L
//