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Database: UniProt
Entry: W5NXR2_SHEEP
LinkDB: W5NXR2_SHEEP
Original site: W5NXR2_SHEEP 
ID   W5NXR2_SHEEP            Unreviewed;       845 AA.
AC   W5NXR2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSOARP00000002959};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002959, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000002959, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002959};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000002959}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000002959}.
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DR   EMBL; AMGL01039159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01039160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01039161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011953080.1; XM_012097690.2.
DR   Ensembl; ENSOART00000003018; ENSOARP00000002959; ENSOARG00000002788.
DR   GeneID; 101121550; -.
DR   KEGG; oas:101121550; -.
DR   CTD; 23545; -.
DR   GeneTree; ENSGT00390000004941; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000002356; Chromosome 17.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    397    421       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    442    459       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    563       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    575    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       85    119       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   845 AA;  97059 MW;  8FFEDBDC62699C01 CRC64;
     MCLAQLFLQS GTAYECLSVL GEKGLVEFRD LNQNVSSFQR KFVGEVKRCE ELERILAYLV
     QEINRADIPL PEGETSPPAP PLKQVLEMQE QLQKLEVELR EVTKNKEKLR KNLLELIEYT
     HMLRVTKTFV KRNVEFEPTY EEFPPLENES LLDYSCMQRL GAKLGFVSGL INQGKVEAFE
     KMLWRVCKGY TIVTYAELDE PLEDPETGEV IKWYVFLISF WGEQIGHKVK KICDCYHCHV
     YPYPNTAEER REIQEGLNTR IQDLYTVLHK TEDYLRQVLC KAAESVYSRV IQVKKMKAIY
     HMLNMCSFDV TNKCLIAEVW CPEADLHELR RALEEGSRES GGTIPSFMNT IPTKETPPTL
     IRTNKFTEGF QNIVDAYGVG SYQEVNPALF TIITFPFLFA VMFGDFGHGF VMFLFALLLV
     LNENHPRLNQ SQEIMRMFFN GRYILLLMGL FSVYTGLIYN DCFSKSVNLF GSRWNVSAMY
     SSSHSPEEQR KMVLWNDSVV RRHGVLQLDP SVPGVFRGPY PFGIDPIWNL ATNRLTFLNS
     FKMKMSVILG ITHMTFGVIL GIFNHLHFRK KFNICLVSIP ELLFMLCIFG YLIFMIIYKW
     LVYSAETSRT APSILIEFIS MFLFLASDTG GLYPGQEHIQ RLLLVITVLS VPVLFLGKPL
     FLLWLHRGRN CFGVSRSGYT LVRKDSEEEV SLLGGQDIEE GNNQMEDGCR EVMCEEFDFG
     EILMTQVIHS IEYCLGCISN TASYLRLWAL SLAHAQLSEV LWAMLMHVGL RVDTTYGVLV
     LLPVIALFAV LTIFILLIME GLSAFLHAIR LHWVEFQNKF YVGAGTKFVP FSFRLLSSKF
     SDDLA
//
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