ID W5P026_SHEEP Unreviewed; 2092 AA.
AC W5P026;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Stabilin-1 {ECO:0008006|Google:ProtNLM};
GN Name=STAB1 {ECO:0000313|Ensembl:ENSOARP00000003774.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003774.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003774.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003774.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003774.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AMGL01045522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000003774; -.
DR PaxDb; 9940-ENSOARP00000003774; -.
DR Ensembl; ENSOART00000003841.1; ENSOARP00000003774.1; ENSOARG00000003517.1.
DR eggNOG; KOG1218; Eukaryota.
DR HOGENOM; CLU_001035_0_0_1; -.
DR OMA; VHAECIP; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000003517; Expressed in mitral valve and 52 other cell types or tissues.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.30.180.10; FAS1 domain; 6.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.90.20.10; Plasmodium vivax P25 domain; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR24038; STABILIN; 1.
DR PANTHER; PTHR24038:SF8; STABILIN-1; 1.
DR Pfam; PF12947; EGF_3; 6.
DR Pfam; PF02469; Fasciclin; 5.
DR Pfam; PF00193; Xlink; 1.
DR SMART; SM00181; EGF; 18.
DR SMART; SM00554; FAS1; 5.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF82153; FAS1 domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS50213; FAS1; 6.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2092
FT /note="Stabilin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870455"
FT DOMAIN 108..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 230..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 354..488
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 500..636
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 717..757
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 850..892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 893..935
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 936..975
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 977..1107
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1117..1242
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1359..1396
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1400..1438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1482..1524
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1567..1693
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1709..1849
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1943..1985
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2019..2092
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT REGION 1454..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 162..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 747..756
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1367..1384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1386..1395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1404..1414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2065..2086
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 2092 AA; 223274 MW; B838BF88D4ABB3FE CRC64;
MAGPRGHLLL CFLALCLAGP SFFGEQKVRS KRCDVKTKFV THIPCTPCPA IKKRACPLGW
TRAFPEKISQ DCRYEVQLGD SLLSMSGCSL ECWKDMVQNP GSWGSQCYEC PGGAETPCSG
HGTCLDGIDG NGTCVCQENF GGSACQECRD PNRFGPDCQS VCRCVYGVCR HGPRGDGSCL
CFAGYTGAHC DHEVLACRAL NCPRNSQCSE EAPSCSCLPG YTQQGHECRA SDPCRPSPCS
PLAQCSVGPR GQAQCRCPEN YYGDGTVCLP QDPCTTNNGG CPSNSTLCLY RRGGQASCLC
KPGLVSIAHD SSAGCFAHCS AFSCDRSATC QVTPDGKTSC VCKEGEVGDG RACYGHLLHE
VQKASQTSML LRLRVAFAML DQGCREILST SGPFTVLAPL VSSRTMNASV AQQLCRQHVI
AGQHMLEEAG AQAPRRWWTL AGQEITVSFS RFRKYTYKYQ DQPQQTFTIH KANYPAANGL
FHVVTALRVQ PPPELPEDPK RTIGQILASN EVFTRFETIL ENCGLPSFLD GPGPFTVFAP
SNEAVDGLRD GQTKTPLSCQ GLSKLQELVR YHVYNHGQLT VEKLISKGRV LTMANQILAV
NISEEGRILL GPEGVPLRRV DVLAANGVIH MLEGILLPPT VYLLPSSPCP AQGSCVDCQA
LNTSTCPPNS VKLDISPEEC VYIHDPTGLN VLRKGCAHYC NQTIQKPGCC KGFFGPDCLQ
CPGGFSNPCY GKGNCSDGVQ GSGACLCFPD YKGIACHICS NPNKHGEQCQ EDCGCVHGLC
DNRPGSGGVC QRGTCAPGFS GRFCNESTVS CGSTEQAQQC HPHARCVNQG GVSRCLCLDA
FEGDGFSCTP SDPCSRPDRG GCSENAECVP GARGAHHCTC HKGWSGDGRV CVAIDECELD
SRGSCHADAL CSYVGPGQSR CTCKLGFAGD GYMCSPIDPC RAGNGGCHDL ATCRAVGGGQ
RVCTCPPGYG GDGFSCYGDI LKELEANAHF SVFYQWVKGA GITFPADSQV TALVPSESAI
RRLSSKDQAF WLQPRLLPQL VRAHFLQGAL SEEELARLHG QNVSTLNPTV RWEIHNVSGR
VWVQNASVDV ADLLATNGVL HVLSQVLLPP RGDVPGGQGL LQQLDAVPAF HLFRELLQRH
RLVPQIEAAT AYTIFVPTNR SLEAQANSSS LDSDVVRHHV ILGEALSTEA LGKGGHRSSL
LGPAHWLVFY NHSGQPEVNH VPLEGPVLQA PGRSLFGLSG VLTVGSSRCL HSHAEALREK
CVNCSRKFRC TQGYQLEDTP RKSCVYRSGY TFSRGCSYTC AKKIQVPDCC PGFFGTLCEP
CPGGLGGVCS GHGQCQDRLP GGGGGPGRAA GEMDGLARSG PNCSGVCDCA HGLCQEGLRG
DGSCICNVGW QGLRCDQKIS GPQCLQKCDP NANCVQDSAA TPACVCAAGY SGDGVSCSAV
DPCARDHGGR APGAGAWARG GRGSPPRADV GWGSGFTPLP PEANSCLIRH GGCHMHAECI
PTGPQQVSCS CREGYSGDGI RACVLLDPCS QNNGGCSPYA VCKSTGDGQR TCACDAVRTV
GDGFTCRARV SLELLRDKHA SFFSLHLLEY KDLKGDGPFT VFVPHADLMT NMSQDELARI
RANRQLVFRY HVVGCRQLRS QELLEEGYAT TLSGHPLRFS EREGNIYIND FARVVSSDQE
AVNGVLHFID RVLLPPEALH WEADAAPALR RNFTAAAEAF GYKIFSGLVT MAGLLPLLQD
SFHRPLTMLW PTDSALQALP PDRQVWLYHK DHRDKLAAIL RGHVIRNVEA LAADLPNLGP
LRTMHGTPIS FSCSRARPGA LTVGEDAARI VQRHLPFEGG LAYGIDQLLE PPGLGARCDR
FETRPLWLKV CSICGLEPPC PPGSQEQVRG WALGGGFRQG PAGAGLQPNP XGCSEHANCS
QVGTAVTCTC WPDYEGDGWS CRARNPCEDG HRGGCSEHAD CLNTGPNTRR CVCHAGYVGD
GLQCLLEPEP PVDRCLDRPP PCHADAVCTD LHFQEKRAGV FHLQAPSGPY GLNFSEAEAA
CGAQGAVLAS LLQLSAAQQL GFHLCLVGWL ANGSAAHPVV FPAADCGDGQ VG
//
