ID W5P055_SHEEP Unreviewed; 871 AA.
AC W5P055;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Rho guanine nucleotide exchange factor 26 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGEF26 {ECO:0000313|Ensembl:ENSOARP00000003803.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003803.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003803.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003803.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01010676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01010677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01010678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P055; -.
DR SMR; W5P055; -.
DR STRING; 9940.ENSOARP00000003803; -.
DR PaxDb; 9940-ENSOARP00000003803; -.
DR Ensembl; ENSOART00000003870.1; ENSOARP00000003803.1; ENSOARG00000003561.1.
DR eggNOG; KOG3523; Eukaryota.
DR HOGENOM; CLU_012820_2_0_1; -.
DR OMA; DRDGQKT; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000003561; Expressed in lung and 53 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 439..623
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 655..782
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 789..850
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..157
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 97588 MW; B00BF442906109D9 CRC64;
MNTESEVDFS SNSLTPLWRR RSTPQPQLLG RSKPRPQSYQ SPSGLLITDF PVEDRETLPA
AQTVAEVPGA SDGRTVQRSP LLICAHRRAV TNGRTVSQEY RAVSPRLRRS KSPQVPRVAS
GGSPQPPANR GTVTKPVPQP LHPPRTPRAP PPCSPEGDKT GFPTSPLPSP AANGLSAISS
QGAGSLSGNM AKDPERGTSR LSPSLPKRSL EQKLPLQRLP SPENELLENP SVVLSTNSPA
ALKVGKQQII PKSLASEIKI SKSNSLNVEP HKRLLKVRSM VEGLGAPLGP AEDEGEAEHD
LDSPGSLRRG LRSTSYRRAV VSGVDFDSPG TSKKKNRMSQ PVLKAVMEDK EKFSSLGRIK
KKMLKGQGTF DGEAENAVLY QNYKEKALDI DSDEESEPKE QKSDEKIVIH HKPLRSTWSQ
LTAVKRNGLS QTVSQEERKR QEAIFEVISS EHSYLLSLEI LIRMFKNSKA LSDTMTKTES
HHLFSNITDV CEASKKFFTE LEARHQNNIF IEDISDIVEK HTASTFDPYV KYCTNEVYQQ
RTLQKLLATN PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS
PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV SSSRWLVKRG
ELTAYVEDTV LFSKRTSKQQ VYFFLFNDVL IITKKKSEES YNVNDYALRD QLLVESCDSE
ELTSSPGKNS STMLYSRQNS ASHLFTLTVL SNHANEKVEM LLGAETQSER ARWITALGHS
SGKQPPDRTS LTQVEIIRSF TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF
PMECAKEITC QATIDKNVER MGRLLGLETN V
//
