GenomeNet

Database: UniProt
Entry: W5P0Y1_SHEEP
LinkDB: W5P0Y1_SHEEP
Original site: W5P0Y1_SHEEP 
ID   W5P0Y1_SHEEP            Unreviewed;      4788 AA.
AC   W5P0Y1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   30-AUG-2017, entry version 26.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOARP00000004080};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOARP00000004080};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004080, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000004080, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004080};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000004080}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000004080}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01070808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01070817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000004152; ENSOARP00000004080; ENSOARG00000003817.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000002356; Chromosome 25.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4108   4127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4328   4348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4395   4414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4531   4552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4589   4610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4665   4688       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        6     61       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       68    113       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      121    176       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      182    238       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      250    307       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      493    703       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      919   1116       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1162   1374       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3851   3886       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4240   4266       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4788 AA;  544719 MW;  4AFC3F80347320AD CRC64;
     AQGGGHRTLL YGHAILLRHS YSGMYLCCLS TSRSSTDKLA FDVGLQEDTT GEACWWTIHP
     ASKQRSEGEK VRVGDDLILV SVSSERYLHL SYGNGSLHVD AAFQQTLWSV APISSGSEAA
     QGYLIGGDVL RLLHGHLDEC LTVPSGEHGE EQRRTVHYEG GAVSVHARSL WRLETLRVAW
     SGSHIRWGQP FRLRHVTTGK YLSLMEDKSL LLMDKEKADV KSTAFTFRSS KTFKEKLDVG
     VRKEVDGMGT SEIKYGDSVC YIQHINTGLW LTYQSVDVKS VRMGSIQRKA IMHHEGHMDD
     GLNLSRSQHE ESRTARVIRS TVFLFNRFIS VKKVKASTVD LPIESVSLSL QDLIGYFHPP
     DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN LVLECIDRLH VYSSAAHFAD VAGREAGESW
     KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE ASSGILEVLH CVLVESPEAL
     NIIKEGHIKS IISLLDKHGR NHKVLDVLCS LCVCHGVAVR SNQHLICDNL LPGRDLLLQT
     RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE LMVDHTEPFV TAEATHLRVG WASTEGYSPY
     PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI
     SFRINGQPVQ GMFENFNIDG LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV
     LPKEKLKVEH SREYKQERTY TRDLLGPTVS LTQAAFTPIP VDTSQIVLPP HLERIREKLA
     ENIHELWVMN KIELGWQYGP VRDDNKRQHP CLVEFSKLPE QERNYNLQMS LETLKTLLAL
     GCHVGISDEH AEEKVKKMKL PKNYQLTSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV
     WARDRIRQGW TYGIQQDVKN RRNPRLVPYA LLDDRTKKSN KDSLREAVRT LLGYGYNLEA
     PDQDHAARAE VCSGTGERFR IFRAEKTYAV KAGRWYFEFE AITSGDMRVG WSRPGCQPDQ
     ELGSDERAFA FDGFKAQRWH QGNEHYGRSW QAGDVVGCMV DMTEHTMMFT LNGEILLDDS
     GSELAFKDFD VGDGFIPVCS LGVAQVGRLN FGKDVSTLKY FTICGLQEGY EPFAVNTNRD
     ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT IDSSPCLKVT QKSFGSQNSS TDIMFYRLSM
     PIECAEVFSK SYCLTPSLLN ERDDYDYLMQ TSTTILQYYY SVRIFPGQEP ANVWVGWITS
     DFHQYDTGFD LDRVRTVTVT LGDEKGKVHE SIKRSNCYMV CAGESLSPGQ GRNNNGLEIG
     CVVDAASGLL TFTANGKELS TYYQVEPSTK LFPAVFAQAT SPNVFQFELG RIKNVMPLSA
     GLFKSEHKNP VPQCPPRLHV QFLSHVLWSR MPNQFLKVDV SRISERQGWL VQCVEPLQFM
     SLHIPEENRS VDILELTEQE ELLKFHYHTL RLYSAVCALG NHRVAHALCS HVDEPQLLYA
     IENKYMPGLL RAGYYDLLID IHLSSYATAR LMMNNEFIVP MTEETKSITL FPDEKKKHGL
     PGIGLSTSLR PRMQFSSPSF VSINTEGYQY SPEFPLDILK AKTIQMLTEA VKEGSLHARD
     PVGGTTEFLF VPLIKLFYTL LIMGVFHNED LKHVLQLIEP SVFKEAASPE EESEVAEKEP
     FVEDSKLEGA AEEENKGGKR PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF
     SDDFVAKLQD NQRFRYNEVM QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKSECPC
     PEEIRDQLLD FHEDLMTHCG IELDEDRSLD GNNDLTIRGR LLSLVEKVTY LKKKQAEKPV
     ESDSKKSSTL QQLISETMVR WAQESVIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI
     NGVSVEDTIN LLASLGQIRS LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH
     ETVMEVMVNV LGGGESKEIT FPKMVANCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG
     LASPAMRGST PLDVAAASVM DNNELALALR EPDLEKVVRY LAGCGLQSCQ MLVSKGYPDI
     GWNPVEGERY LDFLRFAVFC NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLSAME
     EAIKIAEDPS RDGPSPTTGS SRTPDTEEEE DDTIHMGNAI MTFYAALIDL LGRCAPEMHL
     IHAAKGEAIR IRSILRSLIP LGDLVGVISI AFQMPTIAKD GNVVEPDMSA GFCPDHKAAM
     VLFLDRVYGI EVQDFLLHLL EVGFLPDLRA AASLDTAALS ATDMALALNR YLCTAVLPLL
     TRCAPLFAGT EHHASLIDSL LHTVYRLSKG CSLTKAQRDS IEVCLLSICG QLRPSMMQHL
     LRRLVFDVPL LNEHAKMPLK LLTNHYERCW KYYCLPGGWG NFGAASEEEL HLSRKLFWGI
     FDALSQKKYE QELFKLALPC LSAVAGALPP DYMESNYVSM MEKQSSMDSE GNFNPQPVDT
     SNITIPEKLE YFINKYAEHA HDKWSMDKLA NGWIYGEIYS DSSKVQPLMK PYKLLSEKEK
     EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYNRTRRIS QTSQVSVDAA HGYSPRAIDM
     SNVTLSRDLH AMAEMMAENY HNIWAKKKKL ELEAKGGGNH PLLVPYDTLT AKEKAKDREK
     AQDILKFLQI NGYAVSSHPR GFKDLELDTP SIEKRFAYSF LQQLIRYVDE AHQYILEFDG
     GSRSKGEHFP YEQEIKFFAK VVLPLIDQYF KNHRLYFLSA ASRPLCSGGH ASNKEKEMVT
     SLFCKLGVLV RHRISLFGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS ALRAFLDNAA
     EDLEKTMENL KQGQFTHTRN QPKGVTQIIN YTTVALLPML SSLFEHIGQH QFGEDLILED
     VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA FPVAFLETHL DKHNIYSIYN
     TKSSRERAAL NLPTNVEDVC PNIPSLEKLM EEIVDLAESG IRYTQMPHVM EVILPMLCSY
     MSRWWEHGPE NNPGRAEMCC TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAGVRET
     VFSQPIINKV KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL KSEARGDMSE AELLILDEFT
     TLARDLYAFY PLLIRFVDYN RSRAKWLKEP NQEAEDLFRM VAEVFIYWSK SHNFKREEQN
     FVVQNEINNM SFLIMDTKSK MSKKLVQMKA AVSDQERKKM KRKGDRYSMQ TSLIVAALKR
     LLPIGLNICA PGDQELIALA KNRFSLKDTE DEVRDIIRSN IHLQGKLEDP AIRWQMALYK
     DLPNRTEDTS DPEKTVERVL DIANVLFHLE QVEHPQRSKK AVWHKLLSKQ RKRAVVACFR
     MAPLYNLPRH RAVNLFLQGY EKSWIETEEH YFEDKLIEDL AKPGAEPPEE DEGTKRVDPL
     HQLILLFSRT ALTEKCKLEE DFLYMAYADI MAKMYQSCHD EEDDDGEEEV KSFEEKEMEK
     QKLLYQQARL HDRGAAEMVL QTISASKGET GPMVAATLKL GIAILNGGNS TVQQKMLDYL
     KEKKDVGFFQ SLAGLMQSCS YCSVLDLNAF ERQNKAEGLG MVTEEGSVIT HERGEKVLQD
     DEFTCDLFRF LQLLCEGHNS DFQNYLRTQT GNNTTVNIII STVDYLLRVQ ESISDFYWYY
     SGKDVIDEQG QRNFSKAIQV AKQVFNTLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA
     HMQMKLSQDS SQIELLKELM DLQKDMVVML LSMLEGNVVN GTIGKQMVDM LVESSNNVEM
     ILKFFDMFLK LKDLTSSDTF KEYDPDGKGV ISKRDFHKAM ESHKHYTQSE TEFLLSCAET
     DENETLDYEE FVKRFHEPAK DIGFNVAVLL TNLSEHMPND TRLQTFLELA ESVLNYFQPF
     LGRIEIMGSA KRIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE KEKMELFVNF
     CEDTIFEMQL AAQISESDLN ERSANKEESE KEKPEEQGPR MGFFSIMTVK SALFALRYNI
     LTLMRMLSLK SLKKQVKKVK KMTVKDMITA FFTSYWSILM SLLHFVASVF RGFSRIIGSL
     LLGGSLVEGA KKIKVAELLA NMPDPTQDEV RGDGEEGERK TLEGALPSED LTDLKELTEE
     SDLLSDIFGL DLKREGGQYK LIPHNPNAGL SDLMSNPVPI PEVQEKFQEQ KANEEEKEEK
     EESKSEPEKA EGEDGEKEEK AKEDKGKQKL RQLHTHRYGE PEVPESAFWK KIIAYQQKLL
     NYFARNFYNM RMLALFVAFA INFILLFYKV RKELPTRSSS ENARVSSLDS SSPRIIAVHY
     VLEESSGYME PTLRILAILH TVISFFCIIG YYCLKVPLVI FKREKEVARK LEFDGLYITE
     QPSEDDIKGQ WDRLVINTQS FPNNYWDKFV KRKVMDKYGE FYGRDRISEL LGMDKAALDF
     SDAREKKKPK KDSSLSAVLN SIDVKYQMWK LGVVFTDNSF LYLAWYMTMS ILGHYNNFFF
     AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG
     DTPDMKCDDM LTCYMFHMYV GVRAGGGIGD EIEDPAGDEY EIYRIIFDIT FFFFVIVILL
     AIIQGLIIDA FGELRDQQEQ VKEDMETKCF ICGIGNDYFD TVPHGFETHT LQEHNLANYL
     FFLMYLINKD ETEHTGQESY VWKMYQERCW EFFPAGDCFR KQYEDQLN
//
DBGET integrated database retrieval system