GenomeNet

Database: UniProt
Entry: W5P1V0_SHEEP
LinkDB: W5P1V0_SHEEP
Original site: W5P1V0_SHEEP 
ID   W5P1V0_SHEEP            Unreviewed;       380 AA.
AC   W5P1V0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Pregnancy-associated glycoprotein 1-like {ECO:0000313|Ensembl:ENSOARP00000004399.1};
GN   Name=LOC101102275 {ECO:0000313|Ensembl:ENSOARP00000004399.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004399.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000004399.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004399.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000004399.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; AMGL01061567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5P1V0; -.
DR   SMR; W5P1V0; -.
DR   PaxDb; 9940-ENSOARP00000004399; -.
DR   Ensembl; ENSOART00000004476.1; ENSOARP00000004399.1; ENSOARG00000004098.1.
DR   eggNOG; KOG1339; Eukaryota.
DR   HOGENOM; CLU_013253_3_0_1; -.
DR   OMA; DKICRIT; -.
DR   Proteomes; UP000002356; Chromosome 21.
DR   Bgee; ENSOARG00000004098; Expressed in placentome of cotyledonary placenta.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..380
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013153089"
FT   DOMAIN          71..377
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        89
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        270
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        102..107
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        261..265
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        303..338
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   380 AA;  42553 MW;  2A7C866F6AE06C56 CRC64;
     MKWLVLLVLV AFSDCIVKIP LRRVKTMRNT VSGKNMMNNF LKEHACRLSQ ISFCGSNLTT
     FPLRNIMDML YVGNITIGTP PQEFQVLFDT GSSFLWVPSV FCKSSTCSKR IRFRHLQSST
     LRLTDKICRI TYGSRRIKGI VVRDTVRIGD LVSTDQLFGL SLVEYGFEDI PFDGILGLNY
     PNISSAGAIP IVDNLKNQGA ISEPVFAFYL SKYKQEGSVV MFGGVDQRYY KGELNWVPLI
     QVGGWTVHMD CISMKRKVIA CSGGCHADFD TRISLIQGPS TLVNNIQKLI GARQRGSQHY
     VSCSAVNTLP SIIFTINGIN YPVPAQAYIL KDSRGHCCTT FEENKVSSST ENWILGDVFQ
     RLYFSVFDRG NDRIGLARAL
//
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