ID W5P1V0_SHEEP Unreviewed; 380 AA.
AC W5P1V0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Pregnancy-associated glycoprotein 1-like {ECO:0000313|Ensembl:ENSOARP00000004399.1};
GN Name=LOC101102275 {ECO:0000313|Ensembl:ENSOARP00000004399.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004399.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004399.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004399.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AMGL01061567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P1V0; -.
DR SMR; W5P1V0; -.
DR PaxDb; 9940-ENSOARP00000004399; -.
DR Ensembl; ENSOART00000004476.1; ENSOARP00000004399.1; ENSOARG00000004098.1.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_0_1; -.
DR OMA; DKICRIT; -.
DR Proteomes; UP000002356; Chromosome 21.
DR Bgee; ENSOARG00000004098; Expressed in placentome of cotyledonary placenta.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..380
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013153089"
FT DOMAIN 71..377
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 89
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 102..107
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 261..265
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 303..338
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 380 AA; 42553 MW; 2A7C866F6AE06C56 CRC64;
MKWLVLLVLV AFSDCIVKIP LRRVKTMRNT VSGKNMMNNF LKEHACRLSQ ISFCGSNLTT
FPLRNIMDML YVGNITIGTP PQEFQVLFDT GSSFLWVPSV FCKSSTCSKR IRFRHLQSST
LRLTDKICRI TYGSRRIKGI VVRDTVRIGD LVSTDQLFGL SLVEYGFEDI PFDGILGLNY
PNISSAGAIP IVDNLKNQGA ISEPVFAFYL SKYKQEGSVV MFGGVDQRYY KGELNWVPLI
QVGGWTVHMD CISMKRKVIA CSGGCHADFD TRISLIQGPS TLVNNIQKLI GARQRGSQHY
VSCSAVNTLP SIIFTINGIN YPVPAQAYIL KDSRGHCCTT FEENKVSSST ENWILGDVFQ
RLYFSVFDRG NDRIGLARAL
//