ID W5P1W3_SHEEP Unreviewed; 84 AA.
AC W5P1W3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=cAMP-dependent protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667};
GN Name=PKIG {ECO:0000313|Ensembl:ENSOARP00000004412.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004412.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004412.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004412.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004412.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000256|ARBA:ARBA00002844}.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000256|ARBA:ARBA00006393,
CC ECO:0000256|PIRNR:PIRNR001667}.
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DR EMBL; AMGL01026191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P1W3; -.
DR STRING; 9940.ENSOARP00000004412; -.
DR PaxDb; 9940-ENSOARP00000004412; -.
DR Ensembl; ENSOART00000004490.1; ENSOARP00000004412.1; ENSOARG00000004128.1.
DR eggNOG; ENOG502SBS3; Eukaryota.
DR HOGENOM; CLU_163471_2_0_1; -.
DR OMA; CNESACH; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000004128; Expressed in heart right ventricle and 52 other cell types or tissues.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416:SF5; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR GAMMA; 1.
DR PANTHER; PTHR15416; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI; 1.
DR Pfam; PF02827; PKI; 1.
DR PIRSF; PIRSF001667; PKI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REGION 52..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 24
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT SITE 27
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT SITE 28
FT /note="Important for inhibition"
FT /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
SQ SEQUENCE 84 AA; 8680 MW; 94EF946C180B3A9E CRC64;
GLKSDATGMM EVESSYSDFI SCDRTGRRNA VPDIQGDSEA MSVRKLAGDM GELALEGAEG
QAEVGTSDKE ASSQPESSDG TTSS
//
