ID W5P272_SHEEP Unreviewed; 2075 AA.
AC W5P272;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN Name=CKAP5 {ECO:0000313|Ensembl:ENSOARP00000004521.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004521.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004521.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004521.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; AMGL01033363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000004521; -.
DR PaxDb; 9940-ENSOARP00000004521; -.
DR Ensembl; ENSOART00000004602.1; ENSOARP00000004521.1; ENSOARG00000004217.1.
DR eggNOG; KOG1820; Eukaryota.
DR HOGENOM; CLU_000539_2_1_1; -.
DR OMA; NWKERKE; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000004217; Expressed in saliva-secreting gland and 55 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..269
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 311..549
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 482..520
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 628..860
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 892..1124
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1233..1471
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 556..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1991..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2040..2060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2075 AA; 229431 MW; FE37AA7E71BFEEEC CRC64;
MGGPPRTNKQ RGHCGVCGGP SGFKRLRATS RFWPGGGETG STMGDDSEWM KLPVDQKCEH
KLWKARLSGY EEALKIFQKI KDEKSPEWSK FLGLIKKFVT DSNAVVQLKG LEAALVYVEN
AHVAGKTTGE VVSGVVSKVF NQPKAKAKEL GIEICLMYIE IEKGEAVQEE LLKGLDNKNP
KIVVACIETL RKALSEFGSK IILLKPIIKV LPKLFESREK AVRDEAKLIA VEIYRWIRDA
LRPPLQNINP VQLKELEEEW VKLPTGAPKP ARFLRSQQEL EAKLEQQQSA GGDAEGGGDD
GDEVPQIDAY ELLEAVEILS KLPKDFYDKI EAKKWQERKE ALEAVEVLVK NPKLEAGDYA
DLVKALKKVV GKDTNVMLVA LAAKCLTGLA VGLRKKFGQY AGHVVPTILE KFKEKKPQVV
QALQEAIDAI FLTTTLQNIS EDVLAVMDNK NPTIKQQTSL FIARSFRHCT ASTLPKSLLK
PFCAALLKHI NDSAPEVRDA AFEALGTALK VVGEKAVNPF LADVDKLKLD KIKECSEKVE
LVHGKKAGLA ADKKDFKPVP GRAAASGAAG DKDTKDTSAP KPGPLKKAPA AKPGGPPKKG
KPAAQGGTGG TGTKSKKAVE TKEIVEPELS IEVCEEKASA VLPATCIQLL DSSNWKERLA
CMEEFQKAVE LMDRTEMPCQ ALVRMLAKKP GWKETNFQVM QMKLHIVALI AQKGNFSKTS
AQIVLDGLVD KVGDVKCGNN AKEAMTAIAE ACVLPWTAEQ VMSMAFSQKN PKNQSETLNW
LSNAIKEFGF SGLNVKAFIS NVKTALAATN PAVRTSAITL LGVMYLYVGP SLRMFFEDEK
PALLSQIDAE FEKMQGQNPP APTRGISKHS TGGTDEGEDG EEPDDGGSDA VDLLPRTEIS
DKITSELVSK ISDKNWKIRK EGLDEVAAII NEAKFIQPNI GELPTALKGR LNDSNKILVQ
QTLAILQQLA VAIGPNIKQH VKNLGIPVIT VLGDSKNNVR SAALATVNAW AEQTGMKEWL
EGEDLSEELK KENPFLRQEL LGWLAEKLPT LRSTPTDLIL CVPHLYSCLE DRNGDVRKKA
QDALPFFMMH LGYEKMAKAT GKLKPTSKDQ VLAMLEKAKA NMPAKPTASA KATSKPVGGS
APAKFQPASA PAEDSVSGTV DSKPDPKKAK ALGVSSKTKT AQGKKVPSKT SLKEDEDKSG
PIFIVVPNGK EQRMKDEKGL KVLKWNFTTP RDEYIEQLKT QMSSCVAKWL QDEMFHSDFQ
HHNKALAVMV DHLESEKDGV IGCLDLILKW VTLRFFDTNT SVLMKTLEYL KLLFTLLSDE
EYHLTENEAS SFIPYLILKV GEPKDVIRKD VRAILNRMCL VYPASKMFPF IMEGTKSKNS
KQRAECLEEL GCLVESYGMN VCQPTPGKAL KEIAIHIGDR DNAVRNAALN TIVTVYNVHG
DQVFKLIGTL SEKDMSMLEE RIKRSAKRPS AAPVKQVEEK PQRTQSTSSS TNMLRKGPAE
DMPSRLNQAR SMSGHPEAAQ MVRREFQLDL DEIENDNGTV RCEMPELVQH KLDDIFEPVL
IPEPKIRAVS PHFDDMHSNT ASTINFIISQ VASGDINTSI QALTQIDEVL RQEDKAEAMS
GHIDQFLIAT FMQLRLIYNT HMADEKLEKD EVIKLYSCVI GNLISLFQIE SLAREASTGV
LKDLMHGLIT LMLDSRIEDL EEGQQVVRSV NLLVVKVLEK SDQTNILSAL LVLLQDSLLA
TASSPKFSEL VMKCLWRMVR LLPDTINSIN LDRILLDIHI FMKVFPKEKL KQCKSEFPIR
TLKTLLHTLC KLKGPKILDH LTMIDNKNES ELEAHLCRMM KHSMDQTGSK SDKETEKGAS
RIDEKSSKAK VNDFLAEIFK KIGSKENTKE GLAELYEYKK KYSDADIEPF LKNSSQFFQS
YVERGLRVIE MEREGKGRLP TSAGISPQME VTCVPTATST VSSLGNTNGE EVGPSVYLER
LKILRQRCGL DNTKQDDRPP LTSLLSKPAV PTVASSTDML HSKLSQLRES REQHQHSDLD
SNQTHSSGTT TTSSSSTANI DDLKKRLERI KSSRK
//
